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New Method to Gauge Water Content of Drugs

Posted September 17, 2016 12:00 AM by Engineering360 eNewsletter

Quantifying the water content of solid drugs is one of the most commonly performed chemical tests, with an estimated more than 130 million processes carried out annually worldwide. Now, chemists at The University of Texas at Arlington have invented a new method of performing this test that they say is faster, cheaper, and more accurate than the traditional method, known as Karl Fischer titration. The new system can also be automated, thus reducing labor costs for pharmaceutical companies with potential economic benefits for consumers, researchers said.


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Re: New Method to Gauge Water Content of Drugs

09/18/2016 1:05 AM

You can't get your joint lit?

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Re: New Method to Gauge Water Content of Drugs

09/19/2016 11:22 AM

This is absolutely insane, the GC supplies for a single test alone cost more than an entire production run of KFT or LOD tests. Yes faster, but given the current inflated costs of pharmaceuticals.......

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Re: New Method to Gauge Water Content of Drugs

09/19/2016 4:23 PM

Where do you get the idea this costs more than running KF? I suspect the highest costs for both are up front, but pharmaceutical companies can afford this easily.

Some of the ionic liquids mentioned are far more interesting to me than this application, as these may have applications in new cells for energy storage.

Carrier gas might be expensive, depends on if H2 is used and they have generators for that now.

The biggest time constraint in KF titration is getting the sample into the titration chamber, and pulling/keeping out wet air? There are even coulombetric KF titrators now that are pretty fast for near dry products.

Please do enlighten me on what is referred to.

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