If you are »»designing at very low temperature««, like -50C, it is likely that your senses are no longer working, . . . you are frozen.
I assume that you are »»designing for very low temperature«« applications.
The -50C is in the standards, . . . and occurs only once every 20 years when the moon turns blue. And as it is in the standards - you have to design for it. If your equipment can not take it, . . . put a heater on it and keep it warm . . .