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Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Studies

04/07/2010 12:50 PM

Rapamycin, Pfizer's immunosuppressive drug, has been found to reverse the effects of Alzheimer's in two different mouse models of the disease. This drug, which is already FDA approved for transplant rejection suppression, could be prescribed off-label for this use today. The drug would appear to reduce the levels of amyloid-beta-42 in the brain which then appears to reverse the mental deficits caused by the disease.

Further Reading:

http://io9.com/5508523/a-drug-discovered-in-the-soil-of-easter-island-could-cure-alzheimers

http://www.redorbit.com/news/health/1845007/rapamycin_prevents_alzheimers_deficits/index.html

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#1

Re: Immunosuppressive drug found to reverse Alzheimers in two separate mouse studies

04/07/2010 1:13 PM

Thats great, I could not see what side effects of the drug has.

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#2
In reply to #1

Re: Immunosuppressive drug found to reverse Alzheimers in two separate mouse studies

04/07/2010 1:26 PM

Well, it IS an immunosuppressant after all, so infection is a biggie, as are various forms of cancer.

http://www.rxlist.com/rapamune-drug.htm

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#3
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Re: Immunosuppressive drug found to reverse Alzheimers in two separate mouse studies

04/07/2010 1:37 PM

sorry,....other than that, stroke, nausea, kidney failure......even explosive diarrhea.

Interesting, I'll check the site

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#7
In reply to #3

Re: Immunosuppressive drug found to reverse Alzheimers in two separate mouse stu

04/07/2010 3:59 PM

Explosive diarrhea! That could put you on the no-fly list!

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#11
In reply to #7

Re: Immunosuppressive drug found to reverse Alzheimers in two separate mouse stu

04/07/2010 4:07 PM

I sure as hell wouldn't want to be sitting next to you! =b

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#12
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Re: Immunosuppressive drug found to reverse Alzheimers in two separate mouse stu

04/07/2010 4:12 PM

Kind you are since I don't have that condition.

Word is, Boeing and some European flights are now going to put pay toilets on the planes.

If you ever see anyone franticly looking or trying to borrow change, you might want to run to the other end of the plane.

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#14
In reply to #12

Re: Immunosuppressive drug found to reverse Alzheimers in two separate mouse stu

04/07/2010 4:44 PM

that was meant to be the Generic "you" not the Specific "you"....

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#16
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Re: Immunosuppressive drug found to reverse Alzheimers in two separate mouse stu

04/07/2010 4:58 PM

then adult diapers sales should go up at the airports.....was that your tennis shoe that just sqeeked?

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#15
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Re: Immunosuppressive drug found to reverse Alzheimers in two separate mouse stu

04/07/2010 4:56 PM

Ace Ventura, skip to the 3:00 mark and watch to 3:21 mark

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#4

Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Studies

04/07/2010 3:08 PM

GREAT; taking Rapamycin will probably improve my memory enough to remember I´m dieing of an infection due to the immunosupression caused by the treatment of my Alzheimer!

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#5
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Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Studies

04/07/2010 3:26 PM

Hell, they are prescribing Cyclosporine eye drops for dry eye, it is only a matter of time.....

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#6

Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Studies

04/07/2010 3:38 PM

Rapamune itself doesn't sound like a lot of memorable fun. But the important thing is, the studies show alzheimers could be treated by reducing the levels of amyloid-beta-42.

There may be other treatments (existing or to develop) that would achieve the same result, with a less horrible side effect profile.

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#9
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Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Stu

04/07/2010 4:00 PM

Well said.

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#8

Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Studies

04/07/2010 3:59 PM

I believe there are more chances of finding the gene/s responsible for this disease rather than the medicine to revert the consequences.

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#10
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Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Stu

04/07/2010 4:02 PM

Maybe. It would be nice to see both.

"Hopefuly I will never qualify for a GA"

Is that a dare?

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#13
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Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Stu

04/07/2010 4:13 PM

Not actually, I´m a disciple of Marx (Groucho). As my teacher said: If you don´t like my answers, don´t care: i have others! Have a great day ;-)

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#18
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Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Stu

04/07/2010 7:05 PM

Oh, you are the man! Have you read Groucho and Me?

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#19
In reply to #18

Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Stu

04/07/2010 8:05 PM

I would not dare to!

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#22
In reply to #10

Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Stu

04/12/2010 9:32 AM

AH, I've already called his bluff. =b

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#17

Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Studies

04/07/2010 5:37 PM

so we wont have to put mice into care thats nice

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#20

Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Studies

04/10/2010 10:50 AM
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#21
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Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Studies

04/10/2010 10:57 AM
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#23

Re: Immunosuppressive Drug Found to Reverse Alzheimers in Two Separate Mouse Studies

04/15/2010 5:21 PM

Well here's something else that affects amyloid-beta and is promising in a stage 2 clinical trial for alzheimers: IVIG (intravenous interferon gamma). IFN-gamma is a natural product insofar as it is normally present in your body. Side effects reported here, rash, anemia. Not so bad.

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