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Anonymous Poster #1

The Fountain of Youth

12/16/2014 5:57 AM

What factors governs growing old. When cells are capable to repair itself.

How are we able to grow old. Could any sorts be done to reverse it or at least retain the beauty?

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#1

Re: The Fountain of Youth

12/16/2014 7:25 AM

The same factors that govern intelligence.

Or, in your case, the lack thereof.

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Anonymous Poster #2
#2

Re: The Fountain of Youth

12/16/2014 8:31 AM

I have heard, an gland/organ will be naturally disappeared from human's body at the age range of 15 to 18.This gland/organ is vital to avoid natural aging process.

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Anonymous Poster #1
#3
In reply to #2

Re: The Fountain of Youth

12/16/2014 8:33 AM

What organ is it?

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Anonymous Poster #2
#4
In reply to #3

Re: The Fountain of Youth

12/16/2014 8:48 AM

something like thymus.

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#39
In reply to #4

Re: The Fountain of Youth

12/19/2014 1:09 PM

Are you referring to anonathymus? This gland produces hormones that counteract testosterone preventing posting under a genuine name.

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#12
In reply to #3

Re: The Fountain of Youth

12/16/2014 12:51 PM

Not an organ, it's a bone.

For more information, Google search 'Bonehead'.

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#40
In reply to #3

Re: The Fountain of Youth

12/19/2014 1:17 PM

"What organ is it?"

Endocrinologists' term for it is 'HB3', the 'H' designation shorthand for 'Hammond,' after its discoverer.

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#5
In reply to #2

Re: The Fountain of Youth

12/16/2014 8:49 AM

Is that the brain?

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#6

Re: The Fountain of Youth

12/16/2014 9:15 AM
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#32
In reply to #6

Re: The Fountain of Youth

12/19/2014 12:52 PM

Crap, I missed the exit.

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#34
In reply to #32

Re: The Fountain of Youth

12/19/2014 12:56 PM

No loss, its a water park...

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#37
In reply to #34

Re: The Fountain of Youth

12/19/2014 1:00 PM

great, I'll catch the next exit.

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#7

Re: The Fountain of Youth

12/16/2014 10:20 AM

One of the more recent ideas I heard is telomere deterioration over time. This causes less rapid replacement and removal of old cells and certainly some tumors. This is not the only cause of old age.

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#10
In reply to #7

Re: The Fountain of Youth

12/16/2014 11:48 AM

That was thought to be a gateway many decades ago, but the whole process is far more complex than that.

Telomeres put a stop to the division process of cells after a number of cell divisions. It prevents the replication of cells that may have damaged DNA/RNA. Statistically, the more times a cell divides the more likely that the DNA/RNA code becomes corrupted. At least that was how I was taught in pre-med.

Most mutations in DNA/RNA are harmless, but some can quite devastating to the organism, so putting an expiration date on a cell seems to be nature's way of preventing genetic chaos from overrunning the organism.

If memory serves, with each division of a cell a little more of the telomere is cleaved off the end of the DNA. Once a cell's telomere is finally gone the cell then goes through a process of apoptosis, which is essentially a self-distruct process (cellular lysis) to prevent further cell replication.

There have been numerous experimentation with using telomere reverse transcriptase as a protein to rejuvenate telomeres. Telomerase activation may or may not have an adverse effect with the potential of cancers, but it does seem to help slow down the effects of aging.

What we learned so far has shown us that we don't know enough about telomeres, so more research is ongoing and it seems to be resurfacing in the news lately.

Lengthening life spans opens a huge moral dilemma. We already have overpopulation problems and if a mechanism is found to extend life, who will be the privileged ones that are going to get it? Clearly, if we were to add 50% to everyone's lifespan it would seriously aggravate existing population problems.

We may be facing those problems in only a few decades with the rate that research is advancing our knowledge of medicine.

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#13
In reply to #10

Re: The Fountain of Youth

12/16/2014 12:54 PM

I never thought for a minute that there was one and only one cause of cell aging. Well other than the obvious causes of time and entropy. Telomeres will likely be a facet of the aging process.

You do bring up an interesting point on the paradoxical moral dilemma posed by extending life on a planet that already has overpopulation concerns. Like most moral dilemma questions, this one will not have a simple answer that fits all situations.

There is also the question of the quality of life that each of us get in this casino called life. Like most people I was saddened to hear about Robin Williams suicide and wondered why would he do that. Once I heard the coroner had identified diffuse Lewy bodies in his brain I learned to respect his choice.

As complicated and marvelous as our bodies are, there are even more wondrous ways that things can slowly fall apart.

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#14
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Re: The Fountain of Youth

12/16/2014 1:10 PM

"Like most moral dilemma questions, this one will not have a simple answer that fits all situations."

Excellent point.

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#24
In reply to #10

Re: The Fountain of Youth

12/16/2014 11:43 PM

Seem like you always carry the library with you, wow.

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#8

Re: The Fountain of Youth

12/16/2014 10:21 AM

No......you can't stop time.....

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#18
In reply to #8

Re: The Fountain of Youth

12/16/2014 3:19 PM

Looks like a ride on a centrifuge.... Maybe gravity is killing us?

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#9

Re: The Fountain of Youth

12/16/2014 10:42 AM

its NEVER too late to ignore an ANON

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#11
In reply to #9

Re: The Fountain of Youth

12/16/2014 11:48 AM

I'm proof of that! :-)

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#15

Re: The Fountain of Youth

12/16/2014 1:58 PM

Put in simple terms, cells don't repair themselves they grow, replicate exact copies of themselves and then die and repeat this cycle very quickly over the life of the person. The person grows old and dies because the cells don't replicate perfect copies 100% of the time and hence cell degradation and defects develop that result in aging and death. Think repeated generations of sexual inbreeding, but with cells.

Solution - find a way to ensure perfect cell replication 100% of the time or the ability to destroy or prevent damaged cells from replicating.

Many scientists are attempting this, we'll give you the Nobel prize in Medicine if you can accomplish it. Yes we at CR4 have that power.

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#38
In reply to #15

Re: The Fountain of Youth

12/19/2014 1:07 PM

Some feel that this knowledge will be gained when we fully understand the Cancer causes and cycles...

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#16

Re: The Fountain of Youth

12/16/2014 3:11 PM

The root cause of aging is called TIME!

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#21
In reply to #16

Re: The Fountain of Youth

12/16/2014 4:47 PM

I am pretty sure mariage has something to do with it.

Until I got married I was pretty sure I was immortal and justifiable felt like it just like all other guys who have never been married.

Now that I am married ....... Well, Yep I can already feel I'm gonna die now and it's creeping up on me every day little by not so little.

It would appear that women are like Kryptonite to Superman. Occasional short term exposure does little to no long term harm and can even make a guy feel invincible but continual exposure sure take the super right out of a man.

Don't get me started on what has happened to my 'flight time' or my leaping and bounding ability either. It's almost embarrassing now.

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#22
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Re: The Fountain of Youth

12/16/2014 5:25 PM

So, women are sort of like tequila?

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#23
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Re: The Fountain of Youth

12/16/2014 6:09 PM

I don't know. I grew up in the midwest where beer flows like streams.

One or two beers and I have my super suit on. Three or more and I... Well lets just say thats where the leaping, bounding and 'flight times' came into play.

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#35
In reply to #22

Re: The Fountain of Youth

12/19/2014 12:56 PM

Yes, don't down the whole bottle at once, or you get the worm!

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#25
In reply to #21

Re: The Fountain of Youth

12/17/2014 7:01 AM

Maybe its relative, being married just appears to make time go slowly.

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#45
In reply to #25

Re: The Fountain of Youth

12/21/2014 7:26 AM

This makes the guy's misery even worse. ;) "time go slowly"lol

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#17

Re: The Fountain of Youth

12/16/2014 3:17 PM

The fountin a yout is in Joisey.

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#19
In reply to #17

Re: The Fountain of Youth

12/16/2014 3:19 PM

Is Vinny your cousin?

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#20
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Re: The Fountain of Youth

12/16/2014 3:22 PM

Maybe, who wants ta know? You a cop or somthin?

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#46
In reply to #17

Re: The Fountain of Youth

12/21/2014 7:34 AM

Joisey on a stick.lol

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#26

Re: The Fountain of Youth

12/17/2014 1:48 PM

here are some general links related to your question (but I personally believe that telomeres are the root cause) .... tons of info available from a standard google search

(What makes us age? Ticking of cellular clock promotes seismic changes in chromatin landscape associated with aging) http://www.sciencedaily.com/releases/2010/10/101003205928.htm

(Telomeres and Telomerase) http://www.senescence.info/telomeres_telomerase.html

(Anti-Aging Medicine) http://www.senescence.info/antiaging_science.html

(Scientists Turn Back the Clock on Adult Stem Cells Aging) https://www.buckinstitute.org/buck-news/scientists-turn-back-clock-adult-stem-cells-aging

(Immortal Stem Cells for Anti-Aging Therapies) http://www.lef.org/magazine/2010/6/Immortal-Stem-Cells-for-Anti-Aging-Therapies/Page-01

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#27

Re: The Fountain of Youth

12/18/2014 2:36 PM

One good habit , in order to lengthen one's life , is to always look both ways before crossing anything…Even looking up and down first, can help ….

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#28
In reply to #27

Re: The Fountain of Youth

12/18/2014 2:39 PM

Interestingly this advice works just as well with roads as it does with women.

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#29
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Re: The Fountain of Youth

12/18/2014 9:55 PM

Absolutely correct… In the case of women, better to run parallel, until the threat is past, then cross...

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#51
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Re: The Fountain of Youth

12/23/2014 10:38 AM

Just don't let her catch you looking her up and down.

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#30

Re: The Fountain of Youth

12/19/2014 12:11 AM

Many things enable our cells to grow old. The problem is how do we stop them from growing old and rejuvenate themselves to be younger cells.

Several days ago I flew to the Chelsea section of Manhattan (NYC). There I found things that showed me that I am growing very old in some places but others are staying the same or are more alert than before. The young ladies in that area apparently feel that high skirts (we used to call them mini skirts) are attractive, I do too. As they walked by, my eyes grew younger but other parts of my body are not as quickly alerted as the eyes. NOW NOW! My chest is no longer eye candy to anyone younger than me! Solve this and you could be the next Warren Buffet salary wise.

Good Luck, Old Salt

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#31
In reply to #30

Re: The Fountain of Youth

12/19/2014 9:25 AM

Lol, only the body grows old the mind is not.

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#33

Re: The Fountain of Youth

12/19/2014 12:52 PM

1. We grow old by not winning the Darwin Award!

2. Much research has been done by very serious scientists in regards to aging. Henry Eyring was not the least of these. He did a lot of work in the effects of ionizing (and other) radiation on aging.

3. Our cells have to reproduce themselves every so often. There are areas on the genese known as telomeres. Telemeres play a significant role in determining when the cells can no longer regenerate.

4. Entropy. Deal with it. Nothing lasts forever, not even a diamond.

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#36

Re: The Fountain of Youth

12/19/2014 12:59 PM

Last spring I was in Chicago on a extended vacation and was at I believe the Museum of Science and Industry... or maybe it was the Natural History Museum.

There they had a machine that took your picture, then you answered questions such as your age, if you smoke, drink and how much. Your diet and exercises and such.

After which it would show how you age.

This was great, I did it a number of times and answered different to the questions to see the differences, and if there is any truth to it, I started exercising more and made an attempt at eating better...... or less.

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#41
In reply to #36

Re: The Fountain of Youth

12/19/2014 1:39 PM

Sounds like an MSI exhibit, part of the 'Your Body' collection.

The Field Museum (Full name: The Field Museum of Natural History, Chicagoans seldom use the full name) normally doesn't have interactive displays. It doesn't need them, it has Sue. That old gal can pull in the crowds all on her own.

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#42
In reply to #41

Re: The Fountain of Youth

12/19/2014 1:46 PM

I loved the area, That was our second visit. We stayed by Grant Park. walking distance all around the lake front. Love Bubba Gumps.

Now I'm hungry for garlic shrimp.

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#43
In reply to #41

Re: The Fountain of Youth

12/20/2014 11:51 AM

Isn't Sue the T-Rex where the government (FBI) etc. came in and stole the dino from the archeologists who found her? Figures Chitcago would end up with the thing after all the law suits.

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#47
In reply to #43

Re: The Fountain of Youth

12/22/2014 10:28 AM

Yes, Sue was 'relocated' in an FBI raid, but the situation isn't how you're coloring it:

http://en.wikipedia.org/wiki/Sue (dinosaur)#Dispute and auction

In Summary:

  1. The Black Hills Institute paid Maurice Williams, the owner of the land, to allow them to remove and preserve the skeleton.
  2. Williams later claimed that the money was only for access to the land, and that he still owned the skeleton.
  3. Williams was a member of the Sioux Nation, which claimed the skeleton belonged to the tribe.
  4. The land the skeleton was found on was held in trust by the US Department of the Interior, which meant that the skeleton belonged to the Federal Government.
  5. The FBI aided by the (South Dakota) National Guard raided the Black Hills Institute and seized the skeleton, transferring it to the South Dakota School of Mines and Technology (a 'neutral third party') for safe keeping until the true owner (Black Hills Institute, Williams, Sioux Nation, Federal Government) could be determined.
  6. Williams was determined to be the owner, and he decided to put the skeleton up for auction.
  7. The Field Museum won the auction (fighting against private collectors) by enlisting the aid of several corporate and private donors to contribute to the 'war chest.'

From a $500,000 opening bid, rising to $7.6 Million, that was a hard-fought auction to keep Sue available for the public to see, but there was no corruption or back-room dealings in the Field Museum 'winning' Sue. This was one of the times Chicago did things honestly.

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#48
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Re: The Fountain of Youth

12/22/2014 10:35 AM

Gee thanks for clearing that up. There certainly seemed to be a "grey" area as to land boundaries, the fossil location in that grid, etc. I suspect things did actually turn out well this time.

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#49
In reply to #47

Re: The Fountain of Youth

12/22/2014 10:36 AM

I had read about that and was going to mentioned it. I just thought it was risky to buy it without knowing who was the legitimate owner was. The problem with the tribe, is they like to avoid bad press, it not like its a sacred ancestorial burial site. It was just plan and simple about money and a lot of it.

Also it's not so much land boundaries as it is mineral rights.

Ok, off topic here.

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#50
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Re: The Fountain of Youth

12/22/2014 10:50 AM

Yes, I had heard that the judge had decided the case as if the dinosaur remains were minerals, which physically, I suppose they are.

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#44

Re: The Fountain of Youth

12/21/2014 2:35 AM

It would be a hellish place if we all lived forever. Were it a question of money, we'd be living in a world of bankers and lawyers.

Crocs and such 'supposedly' live forever. Urban myth. Adwaita had a good run for his money, but would maybe have rather popped his clogs when he was in his prime. That's a bit sad, but why would anyone want to live forever ?

You could try cryogenics, but it didn't work too good for Cartman in South Park.

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