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You Can't Manage What You Can't Measure

Posted March 09, 2011 8:30 AM by Steve Melito

Researchers at Boston University are using polymerization chemistry to measure pH-responsive nanoparticles that can release cancer-fighting drugs inside of cells. Led by Professor Mark Grinstaff, researchers from the school's departments of chemistry and biomedical engineering are joining forces to measure so-called "smart particles" that swell as their potential of hydrogen (pH) changes.

The nanoparticles under study are prepared using a mini-emulsion polymerization chemistry that combines the high-energy emulsification and free-radical photopolymerization of an acrylate monomer. Varying the pH level of the solution permits a particle-by-particle analysis in terms of both size and concentration.

The Massachusetts researchers hope to use the expandable nanoparticles and their hydrophilic triggers for targeted drug delivery. By measuring the tiny tunable particles with greater accuracy, the team can assess not just physical properties, but also reaction kinetics and drug efficacy. Earlier measurements failed to provide this degree of accuracy and reliability.

Source: Nano Werk


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