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A Nasal Spray Developed that Kills COVID-19

08/12/2020 2:58 PM

This could be a game-changer...

"Scientists have devised a novel approach to halting the spread of SARS-CoV-2, the virus that causes COVID-19. The researchers engineered a completely synthetic, production-ready molecule that straitjackets the crucial SARS-CoV-2 machinery that allows the virus to infect our cells. In an aerosol formulation they tested, these molecules could be self-administered with a nasal spray or inhaler."

https://www.sciencedaily.com/releases/2020/08/200811234951.htm

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#1

Re: A Nasal Spray developed that kills COVID-19

08/12/2020 3:58 PM

I think you're right.

This should allow a worldwide return to normalcy.

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#2

Re: A Nasal Spray developed that kills COVID-19

08/12/2020 5:34 PM

Sounds amazing.

What's the definition of inexpensive will be?

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#3

Re: A Nasal Spray developed that kills COVID-19

08/12/2020 5:45 PM

I like this. The only drawback I see is it does not address the asymptomatic distribution problem. This preventative will help to protect most who use it (nothing in epidemiology is perfect) but the virus will still thrive among those who do not become ill.

I still like this. I hope it pans out.

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#4

Re: A Nasal Spray developed that kills COVID-19

08/12/2020 7:17 PM
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#5
In reply to #4

Re: A Nasal Spray developed that kills COVID-19

08/12/2020 8:19 PM

I'm guessing there were no double-blind trials. Unfortunately, it is human nature to want to believe good news.

Schools really need to do a better job of teaching skepticism. (Also known as critical thought.) That is something seriously lacking in our adult population. There appears to be a tendency to be so 'busy' in our lives that we are willing to take the words of others at their face value without digging into the issue. Just look at how willing some people are to accept a premise because someone else said it was "fact checked".

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#6
In reply to #5

Re: A Nasal Spray developed that kills COVID-19

08/12/2020 10:16 PM

I think people like to look at everything as either black or white, it's easier than debating all the grey area of reality....I also think it is the perception of people that science marches forward and solves all problems and if you look hard enough you can find whatever you're looking for...what's a problem one day is a scientific breakthrough the next, and if this one doesn't work then the next one surely will....nobody stops to read the fine print because they don't have time, they need to go to work or to some activity that demands punctuality, and traffic is always a factor...and everything is satisfaction guaranteed or a full refund is offered anyway, minus a small shipping and handling fee perhaps, but the people are used to getting things that don't work properly once in a while and just take it in stride....another promise unfulfilled, into the garbage it goes, and move on....of course if you're betting your life on something working, then the mediocre quality stings a bit...but if you accept mediocrity in all other things, then why would you expect higher quality in the one thing you depend on the most....

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#7

Re: A Nasal Spray developed that kills COVID-19

08/13/2020 12:04 AM

Lets hope so...

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#8
In reply to #6

Re: A Nasal Spray developed that kills COVID-19

08/13/2020 7:26 AM

Does a pessimist smile when they're right or when they're wrong?

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#9
In reply to #8

Re: A Nasal Spray developed that kills COVID-19

08/13/2020 7:39 AM

Oh I don't think they smile at all...

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#10

Re: A Nasal Spray Developed that Kills COVID-19

08/13/2020 10:01 AM

At the outset a crowdsourced computer network was created by Nvidea and run through several universities to model this form of attack. I committed my gaming system to the effort. They even create a "protein folding game" to help model the almost infinite ways to encapsulate the protein spikes.

This seemed like a promising avenue that had not been tried before.

I see it is in pre publication so the fun is just beginning. Should be another month or so before it is either accepted or returned for editing or discarded as flawed.

Fingers crossed.

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#11
In reply to #4

Re: A Nasal Spray developed that kills COVID-19

08/13/2020 12:44 PM

Maybe I missed it, but the news article you linked does not connect the spray it refers to the to spray in the OP.

However, skepticism is warranted. According to the Science Daily article human trials have not been done ("commence human trials soon") so while the mechanism to prevent viral activity was proven in the lab outside the human body we know little or nothing about it's safety or efficacy in people.

Also - the thread headline is incorrect as the proposed spray does not "Kill".

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#12
In reply to #11

Re: A Nasal Spray developed that kills COVID-19

08/13/2020 3:19 PM

I'm more interested in the unintended consequences....

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#13
In reply to #12

Re: A Nasal Spray developed that kills COVID-19

08/13/2020 4:00 PM

Exactly my point. There are always unintended consequences.

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#14

Re: A Nasal Spray Developed that Kills COVID-19

08/15/2020 9:26 PM

Hey when I get home from an 'exposure' I put a dollop of eucalyptus oil and a few drops of cinnamon oil on a tissue, and take a 5 minute breather to inhale the stuff. It makes perfect sense to kill airborne virus with a volatile agent, and apply an anti-inflammatory while you're at it. Whatever settled on those interior surfaces while you were out. Makes sense for any airborne disease.

There is a bit of research out there on anti-covid natural products, many seem to be in that category of water-insoluble end of the spectrum. Abietene diterpenes and so on. Inhalable products have a big advantage as a first line of defense anyway, for anything that is finding a receptor in your airways....

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#15

Re: A Nasal Spray Developed that Kills COVID-19

08/17/2020 12:37 AM

I suggested a physical immobilisation technique for the virus hovering near the floor of isolation wards, to prevent it from getting out and infesting unsuspecting people or people with protective armoury, but with a chink somewhere.

It is elementary ; a flypaper fixed in a frame with a handle, moved near the floor systematically. This virus is heavy. Has a number of spikes, and not auto-mobile . When the oil paper is swiped, it would create small air currents that would disturb the settled virus molecules and make them immobile when stuck to the surface of the paper.

At least, there would be no side effects .

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#16
In reply to #15

Re: A Nasal Spray Developed that Kills COVID-19

08/17/2020 2:14 AM

The physics get quite involved down at the micron level--I'm not sure that flypaper will be sticky to a virus.

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#17
In reply to #5

Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure

08/17/2020 8:15 AM

Granny Haggard's Cure: A Success Story in the At-Risk Group

In late January, when Trump banned travel to the US of people who had been in China within 14 days (the beginning of the corona virus pandemic in my perception), I resolved to, employ "Ganny Haggard's Cure" at the first sign of any of the publicized symptoms. I have apparently been disease free ever since I made that resolution.

"Granny Haggard's Cure" is my go to treatment for any respiratory distress ever since an old manager of mine(also named Haggard) recommended it and I tried it out. It involves some tepid distilled water, some sodium chloride, some bicarbonate of soda, and a neti pot. GHC is messy but soothing and not unpleasant, unlike OTC cold meds or even plain tap water up your nose. During these months I have applied no other medications and no other symptom treatments. Except for wearing a mask at the grocery store (once the public health "experts" emerged up out of their noise on this issue and my grocery stores began checking for them on entrance) my life has been nearly imperceptibly affected by the pandemic. Some of the stores I used to frequent have been closed or use restricted hours and that has been understandable but still annoying.

I am in the seventy or older group and thus at increased risk for COVID-19 severe outcome. I credit my disease free state to my resolution to use GHC prophylaxis at the least indication of symptoms. I live in an urban county in TX with all of the recent exasperating behaviors urban dwellers have been expressing in recent months frighteningly close. As best I can I avoid those happenings.

As one final kudo to my resolution to use GHC as my sole treatment for COVID-19, I would like to observe that since I have exhibited no symptoms, GHC is even more impressive. What other therapeutic regimen so unnerves a pandemic disease that it succumbs to the mere threat of its use ? Some have claimed in personal emails that it is my troglodyte lifestyle which has prevented my infection with COVID-19 but I still believe that it is "Old Granny Haggard" who really deserves the credit. Come to think of it, Granny Haggard also recommended a troglodyte lifestyle !

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#18
In reply to #16

Re: A Nasal Spray Developed that Kills COVID-19

08/17/2020 8:27 AM

I don’t know much about the physics of adhesion of insects to fly paper, but I know for certain that such a paper left open outside attracts lot of dust, strands of human hair, bits of dry flower petals floating around etc .

of course, I didn’t have access to Coronavirus to test whether it gets inextricably attracted to a fly paper .

And I am in small town in our country where trying such harebrained ideas is rather difficult .

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#19
In reply to #17

Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure

08/17/2020 8:37 AM

Without proof of your prolonged exposure to people with covid19, this is meaningless... I suspect most people, including myself, owe their success in dodging this bug to limiting exposure to other people and good hygiene...I might add that failure to flush the eyes is a loophole in your strategy...

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#20
In reply to #19

Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure

08/17/2020 9:23 AM

SE,

You missed the fact that I never actually used GHC at all during this pandemic. I merely threatened to use it.

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#21
In reply to #17

Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure

08/17/2020 9:36 AM

I am also in the high risk group.

One must be very careful when making home-brew nasal spray or rinse.

Many have become sick or infected with home remedies.

Tap water may contain harmful bacteria,best to use distilled water.

The concentration of the salt is crucial.Around .65% is ideal.

This is hard to achieve outside of a lab environment.

Water follows the salt due to osmosis,so saline concentration must be slightly more than blood level of sodium chloride,which is around .4%;almost equal to seawater.

This will increase moisture in the sinuses and cause drainage,which will tend to flush the drainage system.

Table salt also includes other ingredients to stabilize it and prevent clumping.

Also consider iodized,or non iodized salt.

Salt alone kills viruses.

Many brands of saline nasal sprays are available over the counter that are sterile and have the right proportions of salt and other buffering agents.

I have been using them for years for sinus problems.

I used to have frequent sore throat,so after a few trips to an ENT doctor,he gave me some very good advice.

He recommended that when I feel the first sign of a sore throat,drink a glass of buttermilk slowly.

In addition to soothing,it absorbs bacteria from the throat and takes them to your stomach where stomach acid kills them,but some are weakened,producing a sort of "vaccine" made by your body.

I have been using this method for over 50 years at the first sign of a sore throat,and it stops it in it's tracks.

This is only empirical data based on my personal experience,so take it for what it's worth.

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#22
In reply to #17

Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure

08/17/2020 9:43 AM

Grandpa had a remedy for the common cold called the "2 hats" remedy:

Hang your hat on the foot board post of the bed.

Get a bottle of your favorite whiskey.

Drink until you see 2 hats at the foot board.

You will have a hangover the next day,

Drink gallons of water.

When the hangover is gone,so is your cold.

Does not work for me,cause I never get a hangover.

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#23
In reply to #5

Re: A Nasal Spray developed that kills COVID-19

08/17/2020 10:33 AM

You have a good point, we do need to be skeptical about any claims. In this case, it seems the claims may have some logical justification. If the COVID virus enters the lung cells using their "spikes" and these spikes can be deactivated, the virus cannot destroy the lung cells and reproduce.

"Further experiments, including the use of cryo-electron microscopy to visualize the nanobody-spike interface, showed that the most potent nanobodies blocked spike-ACE2 interactions by strongly attaching themselves directly to the spike RBDs. These nanobodies function a bit like a sheath that covers the RBD “key” and prevents it from being inserted into an ACE2 “lock.”

IMHO, demonstrating how something works makes a stronger case.

https://www.ucsf.edu/news/2020/08/418241/aeronabs-promise-powerful-inhalable-protection-against-covid-19

https://www.biorxiv.org/content/10.1101/2020.08.08.238469v1

Still, it remains to be seen whether this works as well in the body and does not cause any unforeseen side effects. Time will tell...

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#24

Re: A Nasal Spray Developed that Kills COVID-19

08/17/2020 11:07 AM

I Dont know about game changer but definitely a serious Profit center.

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#25
In reply to #23

Re: A Nasal Spray developed that kills COVID-19

08/17/2020 11:15 AM

The spikes are the mechanism many Coronavirus uses to enter a cell without killing the cell immediately. The very high brightness of x-rays at the NSLSII allows for crystallography with very small crystals of proteins. At the NSLSII cryo-electron microscopy capabilities have just been added so samples identified with one instrument can just be transferred down a hallway for comparisons.

Still, claiming that a nasal spray works to inhibit this delicate and difficult to detect mechanism so relatively soon after this disease appears just reeks of charlatanism. We all want a remedy soon. This is the time window of knowing part of a problem is where con-men thrive. Be careful!

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#26
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Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure. Eyes...?

08/17/2020 11:26 AM

WRT Eye Vulnerability

As you can see, a troglodite mask covers the eyes as well as the nose and mouth, but still with plenty of space for a beard egress. One famous troglodite, often referred to as "the black bag" once attended college with nothing but his flip-flop feet visible to observers. Conveniently, many types of black cloth provide one-way visibility right through the cloth. Like other masks, this mask may not perfectly protect the covered features but I have never been one who allows "perfect" to become the enemy of "good." I judge that this mask will intercept most incoming and outgoing liquid aerosols from or to the eyes. Sometimes I "face paint" phony eyes just above the mask in order to keep grocery clerks from asking if it is a robbery. When I get a RountTuit I intend to embroider some "eyes" directly on the mask but still higher than the real eyes beneath. I would even like to make the "embroidered eyes" continually change their eye-to-eye spacing just to further confuse face recognition software. ET black wrap-around, almond eyes might also be nice and they might also be kinetic but near actual eye level.

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#27
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Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure. OTS version

08/17/2020 11:40 AM

HTRN said:

"Table salt also includes other ingredients to stabilize it and prevent clumping.

Also consider iodized,or non iodized salt.

Salt alone kills viruses."

Which is why I said "sodium chloride" instead of saying "table salt." At one point I had USP after it but I decided that needed explaining and my posts are frequently too long anyway so I dropped it. I also avoided specifying quantities just to discourage some clueless someone from actually implementing it "according to my recipe" and goofing it up. I like your commercial product thought.

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#28
In reply to #26

Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure. Eyes...?

08/17/2020 12:46 PM

After conferring with several Trog's, I'm assured their masks look nothing like that....

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#29
In reply to #28

Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure. Not Masks.

08/17/2020 1:31 PM

Real Trogs Don't Need No Stinkin Masks

Those are not masks. The just took their masks off and sent you an asis photo.

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#30

Re: A Nasal Spray Developed that Kills COVID-19

08/17/2020 3:25 PM

Friends,

As JRiversW said, much needs to be done in the way of testing for toxicity, human trials, etc. Peer review is, of course, necessary. It appears that this report has already received very wide distribution and attention.

My concerns include

  • Unexpected or late-discovered side effects.
  • Inactivation of it by other proteins, biological agents, etc. that may render some populations resistant to this form of disease prevention.
  • Doing studies with a true double-blind methodology.
  • Ensuring that there is no cross-contamination of "placebo" or "inert" test aerosols with active-ingredient aerosols. This is particularly important because of the reported activity at extremely dilute concentrations--"femto molar".
  • Placing blind trust on a new or single treatment and failing to pursue other appropriate preventive treatments.
  • Finding that the aerosol is active against other viral particles in ways that can actually be harmful to life.

In short, the promise is there, but the questions should not be overlooked.

--JMM

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#31
In reply to #29

Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure. Not Masks.

08/17/2020 8:48 PM

Didn't they sing "Wild Thing" ???

https://www.youtube.com/watch?v=4qHX493bB3U

Oh, troglodytes, like in the worst song of the seventies:

https://www.youtube.com/watch?v=BCV6paTXyCU

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#32
In reply to #31

Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure. Earlier Trog

08/17/2020 10:06 PM

43,000 BC

Yep. Troglodytes sang about wild things and played music on the bones of fearsome beasts.

Here is one I remember: I think his name was Biding cause he always seemed to be down in his basement hole just biding his time. At some point I think he drafted a sidekick from the Harries, but they were never able to really get along since Comealong Harries was always upstaging him without even trying.

An early human playing a flute.

Fine Art Images/Heritage Images/Getty Images

As far back as 43,000 years ago, shortly after they settled in Europe, early humans whiled away their time playing music on flutes made from bird bone and mammoth ivory. The instruments were found in a cave in southern Germany in 2012, and are believed to have been used in religious ritual or simply as a way to relax.

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#33
In reply to #32

Re: A Nasal Spray developed that kills COVID-19. Granny Haggard's Cure. Earlier Trog

08/18/2020 11:21 PM

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#34
In reply to #24

Re: A Nasal Spray Developed that Kills COVID-19

08/18/2020 11:26 PM

I wired some red LED's inside a baseball hat for you.

Considering how much money you spent for it, of course it will work. You would never want to admit that it didn't.

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#35
In reply to #34

Re: A Nasal Spray Developed that Kills COVID-19

08/19/2020 10:01 AM

DUDE!

That was my exact same thought the first time I saw that Capillus thing. I laughed so hard my wife came to see what was so funny.

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#36
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Re: A Nasal Spray Developed that Kills COVID-19

08/19/2020 1:32 PM

But it was cleared by the FDA.

(They didn't say it would work, it just won't hurt you.)

Nothing short of amazing is the power of marketing.

(P.T. Barnum's quote he never said not withstanding.)

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#37

Re: A Nasal Spray Developed that Kills COVID-19

01/07/2021 8:29 PM

I don't think that's true. The idea is to use the weakened virus as a "truck" to deliver genetic instructions to cells in the nose and throat, which in turn will create powerful antibodies to prevent SARS-CoV-2 from entering our bodies. I don't think this method will suit everyone. Social distance, self-isolation, passes and other restrictive measures are so deeply embedded in our lives that there is no escape from this. The pandemic will pass, and many moments will remain with us for a long time-a fact. I had symptoms similar to covid and immediately decided to take the test.

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