Physical, chemical, thermal properties are all enhanced as the density goes up.
But, the one potential problem may be in low temperature performance and thermal expansion/contraction. As plastics cool they shrink faster than metals. (This is what doomed the space shuttle that exploded, O-rings act differently than coatings on metals but still shrink faster.)
You need to talk to a pipe supplier. Post the question on Global Spec.
Couldn't find the properties for pipe grade MDPE Film grade was the closest i could get in under a minute. Those Data-sheets are only the overview for the entire family. If your looking for more specific information such as brands or variations of the material just utilize MATWEB.
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Re: MDPE AND HDPE