Previous in Forum: STEM CELLS Used to Create a Working Lung for Transplant   Next in Forum: Can Optogenetics Be Used To Find Specific Memories In Groups Of Neurons.
Close
Close
Close
3 comments
Active Contributor

Join Date: Jun 2014
Posts: 23

Can Xrays Make The Skull Transparent For Microscopy To View The Brain Better

06/10/2014 9:52 PM

Question 1. Is it possible to combine 3 photon microscopy, with X-Rays, or FMRI, PET, and CT machines, to be able to see the brain better.Because in airports they use X-rays that can see into peoples luggage in real time as it passes through the X-Ray machine on the conveyor belt.

Socan X-Rays be used to X-Ray the skull so that it could be possible tomake the skull of the animal, or person transparent in real time, like the X-Ray machines make the surface of the bag transparent to seethe objects inside.

Then when the skull is made transparent by the x-Ray, the 3 photon microscopy machine wouldthen start to image thebrain.So it's as if the the X-Raymachine had made the human skull transparent like glass, so that the microscopy machine could see past the skull, and deeper into the brain.3 photon microscopy can just see around 1.7mm deep into brain a mousesbrain tissue, and just see deep enough to see intothe mouse hippocampus.

The human skull is too thick formicroscopy to get through, microscopy can see 1.7mm deep from the surface of the mouses brain, with the mouses skull being completely removed.So by making the skull transparent with X-Rays it's like the skull has been completely removed, and it gives extra distance forthemicroscopy machine, if it can start to image from the surface of the brain, rather than from the surface of theskull.Researchers say the depth limit of microscopy can be improved, and increased to see deeper into the mousesbrain.So could combining microscopy, withX-Rays, or other kinds of neuroimaging work, and make the skull transparent inreal time, like it was made of glass, so that microscopy could image through the skull to see the brain better.

Register to Reply
Pathfinder Tags: neuroimaging xrays
Interested in this topic? By joining CR4 you can "subscribe" to
this discussion and receive notification when new comments are added.

Comments rated to be Good Answers:

These comments received enough positive ratings to make them "good answers".
3
Guru

Join Date: Jun 2013
Location: Central Canada
Posts: 677
Good Answers: 28
#1

Re: Can Xrays Make The Skull Transparent For Microscopy To View The Brain Better

06/11/2014 10:50 AM

Short answer : NO.

X-rays are absorbed by structures they encounter. Dense structures absorb more of the X-ray beam than structures of lesser densities. This is the principle by which X-ray imaging works. X-ray does not make anything transparent; it helps to identify which structures are more or less opaque.

The problem with a brain encased in a skull was resolved by the advent of Computed Tompography Scanners; and their cousins MRI and PET and others.

However, using X-ray at the surface of an object to render it "transparent" reveals a basic misunderstanding of the process involved.

To your example, the "skin" or outer layers of the luggage are not transparent, but represent a component in the absorption profile at every point in the image.

__________________
Smart as a post and twice as fast.
Register to Reply Good Answer (Score 3)
Active Contributor

Join Date: Jun 2014
Posts: 23
#2
In reply to #1

Re: Can Xrays Make The Skull Transparent For Microscopy To View The Brain Better

06/11/2014 5:40 PM

great thanks for your answer, it was a idea that I though was possible

Register to Reply
Guru
Popular Science - Cosmology - Let's keep knowledge expanding Engineering Fields - Retired Engineers / Mentors -

Join Date: Dec 2006
Location: North America, Earth
Posts: 4384
Good Answers: 104
#3

Re: Can Xrays Make The Skull Transparent For Microscopy To View The Brain Better

06/12/2014 12:49 PM

A CT scan is already x-rays:...

__________________
“I would rather have questions that can't be answered than answers that can't be questioned.” - Richard Feynman
Register to Reply
Register to Reply 3 comments
Interested in this topic? By joining CR4 you can "subscribe" to
this discussion and receive notification when new comments are added.

Comments rated to be Good Answers:

These comments received enough positive ratings to make them "good answers".
Copy to Clipboard

Users who posted comments:

LongintheTooth (1); Nicholas Lee (1); StandardsGuy (1)

Previous in Forum: STEM CELLS Used to Create a Working Lung for Transplant   Next in Forum: Can Optogenetics Be Used To Find Specific Memories In Groups Of Neurons.

Advertisement