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Scientists Find Possible Cure for Age-related Blindness

12/02/2020 7:21 PM

"Harvard Medical School scientists have successfully restored vision in mice by turning back the clock on aged eye cells in the retina to recapture youthful gene function.

The team's work, described Dec. 2 in Nature, represents the first demonstration that it may be possible to safely reprogram complex tissues, such as the nerve cells of the eye, to an earlier age.

In addition to resetting the cells' aging clock, the researchers successfully reversed vision loss in animals with a condition mimicking human glaucoma, a leading cause of blindness around the world.

The achievement represents the first successful attempt to reverse glaucoma-induced vision loss, rather than merely stem its progression, the team said. If replicated through further studies, the approach could pave the way for therapies to promote tissue repair across various organs and reverse aging and age-related diseases in humans."...

..."For their work, the team used an adeno-associated virus (AAV) as a vehicle to deliver into the retinas of mice three youth-restoring genes—Oct4, Sox2 and Klf4—that are normally switched on during embryonic development. The three genes, together with a fourth one, which was not used in this work, are collectively known as Yamanaka factors.

The treatment had multiple beneficial effects on the eye. First, it promoted nerve regeneration following optic-nerve injury in mice with damaged optic nerves. Second, it reversed vision loss in animals with a condition mimicking human glaucoma. And third, it reversed vision loss in aging animals without glaucoma."...

https://medicalxpress.com/news/2020-12-scientists-reverse-age-related-vision-loss.html

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Guru

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#1

Re: Scientists find Possible Cure for age related Blindness

12/02/2020 7:51 PM

Still 20/20 in my left eye, but every 10 weeks visit to ophthalmologist for freezing and needle in right eye to stabilize but not cure a condition. Not exactly a day at the spa. Advances in vision restoration research is good news.

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#2

Re: Scientists find Possible Cure for age related Blindness

12/02/2020 9:59 PM

Certainly sounds promising especially for those of us approaching that age range.

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#3
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Re: Scientists find Possible Cure for age related Blindness

12/02/2020 11:52 PM

I especially like the part about reversing age in other organs...if this works for the heart and brain then we add in the oxygen therapy, well that's pretty much the fountain of youth discovered....

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Re: Scientists find Possible Cure for age related Blindness

12/03/2020 4:20 AM
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#5
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Re: Scientists find Possible Cure for age related Blindness

12/04/2020 5:17 PM

Thank you for the article. You are indeed a wealth of information! Prolific I'd say...

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