Question 1. Is it possible to combine 3 photon microscopy, with X-Rays, or FMRI, PET, and CT machines, to be able to see the brain better.Because in airports they use X-rays that can see into peoples luggage in real time as it passes through the X-Ray machine on the conveyor belt.
Socan X-Rays be used to X-Ray the skull so that it could be possible tomake the skull of the animal, or person transparent in real time, like the X-Ray machines make the surface of the bag transparent to seethe objects inside.
Then when the skull is made transparent by the x-Ray, the 3 photon microscopy machine wouldthen start to image thebrain.So it's as if the the X-Raymachine had made the human skull transparent like glass, so that the microscopy machine could see past the skull, and deeper into the brain.3 photon microscopy can just see around 1.7mm deep into brain a mousesbrain tissue, and just see deep enough to see intothe mouse hippocampus.
The human skull is too thick formicroscopy to get through, microscopy can see 1.7mm deep from the surface of the mouses brain, with the mouses skull being completely removed.So by making the skull transparent with X-Rays it's like the skull has been completely removed, and it gives extra distance forthemicroscopy machine, if it can start to image from the surface of the brain, rather than from the surface of theskull.Researchers say the depth limit of microscopy can be improved, and increased to see deeper into the mousesbrain.So could combining microscopy, withX-Rays, or other kinds of neuroimaging work, and make the skull transparent inreal time, like it was made of glass, so that microscopy could image through the skull to see the brain better.
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