I know that the CR4 community appreciates the necessity that scientific research be reproducible, among other requirements. A few years ago an academic researcher, John Ioannidis from Stanford, asserted that most published research findings are false. He made this claim despite the fact that academic publishers send this stuff out for (impartial) review. His claim spawned research to test whether research was indeed bogus. The Chronicle of Higher Education has an interesting article about some of the results.
When you think about how scientific research affects us individually and as a society, you realize how much we rely on the scientific method to work as planned ... and for peer review to do its job.