Binary Bio-Weapons

Anybody trying something like this in anything but a closely controlled lab, would probably contaminate themselves...so the problem would solve itself...Precisely targeted cheap weapons are where it's at in warfare these days...complicated expensive dangerous experimental devices, not so much.... This is a little too science fictiony to dwell on, imo...besides the word would get out that you were working on something like this, it would take years of targeted effort, and that cannot be done in total secrecy...

There is nothing "complicated" about introducing high levels of an activation protease into an environment to cause pathogenicity in a normally benign infection.
Using the term "weapon" infers political conflict. There are other possible motives.
You make the point that the actors would be put at risk by their own actions. This would not be the case if the actors used a protease inhibitor to reduce pathogenicity.
"A little too science fictiony --" - Just the opposite, protease activation of pathogenicity is well understood and the technologies to mass produce proteases and inhibitors is fully mature.

With that in mind, a binary virus could eventually be targeted to individual DNA strands. Now THAT is scary. If the action of the virus would be delayed and spread over a long enough time for all targets to be infected, any person or their family tree could be the target. Over a period months or of years, perhaps?

Isolation would be possible if you did not carry any targeted DNA strands.(Which in my opinion is nearly impossible. We are all related at some point in our ancestry.)

"Sci-fi-ish"? Si fi has almost always been prophetic.

..."Si fi has almost always been prophetic."...

Ha ha, yeah sure...

Jules Vern, 1869-70 20,000 leagues under the sea. He also predicted the launch site within a few miles, of the real moon rocket, although the depiction shown is quite comical.

In The Year 2889 , + Paris in the Twentieth Century J Vern,

see link:https://lithub.com/on-the-1863-novel-that-predicted-the-internet-cars-skyscrapers-and-electro

nic-dance-music/

Geosynchronous orbit, Arthur C. Clarke in 1945.Also, space elevators, but we are not there yet, but will be someday. Harvesting free energy from the ionosphere?

Like using the "because we can" and "it pays good" motives to introduce ablated modern metallurgy into the solar plasma. I know, I know, its all about scale. Like pioneers believing we could impact fish stocks or timber resources.
Need something done, get out the checkbook, screw the "Law of Unintended Consequences."
Given human history there is nothing more dangerous than well motivated scientists and engineers, dying proof that "everybody has their price?"

Now that is scary. You are suggesting the possibility of attacking specific genetic lineage? Yikes!!

Not just the Chinese. Several universities in the US were involve UNC Chapple Hill in particular

Binaural beats can make the brain hear frequencies that are beyond normal hearing. Perhaps this could explain the Havana Syndrome effects on people all over the world. It can also cause other illusionary effects, even possibly damage the brain if of sufficient amplitude and directed to a small focal point(s).

https://www.webmd.com/balance/what-are-binaural-beats

It can be used for good or bad purposes, as can any technology.

Two for one sale on an activation protease anyone?
Interesting find?
TMPRSS2 is an activation protease for both Sars-CoV2 and H5N1.
A possible implication here is that a single protease could be used to activate multiple binary bio-weapons.
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ABSTRACT
Cleavage of the influenza A virus (IAV) hemagglutinin (HA) by host proteases is indispensable for virus replication. Most IAVs possess a monobasic HA cleavage site cleaved by trypsin-like proteases. Previously, the transmembrane protease TMPRSS2 was shown to be essential for proteolytic activation of IAV HA subtypes H1, H2, H7, and H10 in mice. In contrast, additional proteases are involved in activation of certain H3 IAVs, indicating that HAs with monobasic cleavage sites can differ in their sensitivity to host proteases. Here, we investigated the role of TMPRSS2 in proteolytic activation of avian HA subtypes H1 to H11 and H14 to H16 in human and mouse airway cell cultures. Using reassortant viruses carrying representative HAs, we analyzed HA cleavage and multicycle replication in (i) lung cells of TMPRSS2-deficient mice and (ii) Calu-3 cells and primary human bronchial cells subjected to morpholino oligomer-mediated knockdown of TMPRSS2 activity. TMPRSS2 was found to be crucial for activation of H1 to H11, H14, and H15 in airway cells of human and mouse. Only H9 with an R-S-S-R cleavage site and H16 were proteolytically activated in the absence of TMPRSS2 activity, albeit with reduced efficiency. Moreover, a TMPRSS2-orthologous protease from duck supported activation of H1 to H11, H15, and H16 in MDCK cells. Together, our data demonstrate that in human and murine respiratory cells, TMPRSS2 is the major activating protease of almost all IAV HA subtypes with monobasic cleavage sites. Furthermore, our results suggest that TMPRSS2 supports activation of IAV with a monobasic cleavage site in ducks.
IMPORTANCE Human infections with avian influenza A viruses upon exposure to infected birds are frequently reported and have received attention as a potential pandemic threat. Cleavage of the envelope glycoprotein hemagglutinin (HA) by host proteases is a prerequisite for membrane fusion and essential for virus infectivity. In this study, we identify the transmembrane protease TMPRSS2 as the major activating protease of avian influenza virus HAs of subtypes H1 to H11, H14 and H15 in human and murine airway cells. Our data demonstrate that inhibition of TMPRSS2 activity may provide a useful approach for the treatment of human infections with avian influenza viruses that should be considered for pandemic preparedness as well. Additionally, we show that a TMPRSS2-orthologous protease from duck can activate avian influenza virus HAs with a monobasic cleavage site and, thus, represents a potential virus-activating protease in waterfowl, the primary reservoir for influenza A viruses.
KEYWORDS: influenza virus, TMPRSS2, hemagglutinin, monobasic cleavage site, virus-activating protease, primary airway cells, avian influenza, morpholino oligomers
https://pmc.ncbi.nlm.nih.gov/articles/PMC8475512/?fbclid=IwY2xjawOTHq1leHRuA2FlbQIxMQBzcnRjBmFwcF9pZBAyMjIwMzkxNzg4MjAwODkyAAEe8qqHFuerSneY5v8k2x0U0KqBjw8ZoDcLaYYo1ZmpOTbgocy8BI-QJb-0efw_aem_7NVAHYdPktKiR_y6ajQG3Q

Could you elaborate on that please?

Easy (haha) ! if I understand the Article correctly, it means TMPRSS2 can be used from Waterfowl ( Ducks for example ) to transfer / transmit to other Birds ( Bird Flu ) which can be caught by humans !
It all comes back to the Influenza Bug, not to be confused with the Influencer Bug which seems to be of human origin and serves no useful purpose other than boosting a persons self-image !
Amazing how some people actually follow these "Influencers" !