Steam Autoclave Keeps Opening Pouches

Without knowing the specifics, 'end cap' makes me think closed container. The pressure within the 'pouch' will force it open during the vacuum steam cycle. I have had this happen with test vials when the cap is not vented. I'm no expert but have used our autoclave frequently for steri tests.

Thanks for your comment

I agree with making sure that the pouches are vented.

If they are, then you may have a problem with the autoclave exhausting or vacuuming at too fast a rate. The rapid pressure drop will cause even a vented container to rupture.

you need to have a steam air & mixture in order to sterilize the pouches. The air overpressure will prevent the pouches from opening. This is standard when sterilizing this type of product.