Animal Trial Lab/Model

Just did a quick search of "acute ischemic stroke rat" at PubMed, and it seems that middle cerebral artery occlusion MCAO is a standard method of induction: for example:http://www.ncbi.nlm.nih.gov/pubmed/20138164

http://www.ncbi.nlm.nih.gov/pubmed/20100543

There are other methods as well, you'll find them by reading more of the 450 or so entries to that search.

I should have been clearer in my original question. I am looking for a large animal model. It is for the evaluation of a device rather than a drug.

EB

Eamon,

Here's an overview of the models: you can see for yourself which ones are applicable to a large animal. Drug or device evaluation would not make a difference to the model for inducing a stroke, afaict from a glance these established models are all physical methods related to the obstruction of blood flow.

http://en.wikipedia.org/wiki/Animal_models_of_ischemic_stroke

Hi Artsmith,

This is a nice review, I hadnt thought of looking on Wiki. There is one good paper referenced in the review from my perspective. You are correct that it makes no difference whether it is a large or small animal for inducing the stroke. However, testing a device on a small animal is of little value.

Thanks,

Eamonb

I expect you'll be wanting to watch for the results of this human trial.

But if you are looking for a drug-induced stroke model, try this search:

http://www.google.ca/#hl=en&source=hp&q=drugs+increase+risk+of+stroke&btnG=Google+Search&meta=&aq=f&oq=drugs+increase+risk+of+stroke&fp=b40b83f8bae2b677