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Anonymous Poster

ADA Alert Day: High Glucose in the Blood

03/24/2010 8:53 AM

High blood glucose is HYPERglycemia not HYPOglycemia. Through your description of diabetes, you focus on the response to insulin. Try to think of diabetes with the level of blood glucose as the variable to be controlled.

As we eat, nutrients are converted to glucose. Glucose (or dextrose) is the active ingredient in corn syrup, so this is a quick injection into the circulation. Parts of starches, amino acids, and fats can be converted into glucose if they aren't used for other things. Avoiding sugar, therefore, doesn't mean you run without glucose, you just change the rate glucose enters the system.

Insulin is released in response to hyperglycemia. Not all cells need insulin to use sugar (the heart, the brain, muscle), but storage locations (liver, fatty tissue) do. Regular excercise becomes a glucose sink by moving that sugar into the muscles to produce energy. Mental activity also uses a fair amount of sugar!

The effect of insulin is countered by glucocorticoids. These are released in response to stressful conditions. They get the body ready for fight or flight and cause the release of sugar into the blood. These two hormones regulate glucose levels in the blood and are supposed to cross regulate each other. Like any control system, steady state operations can disturbed and the system is challenged to recover. When it can't, chronic hyperglycemia produces the symptoms of diabetes.

Before the 1920's a diagnosis of diabetes was a death sentence. As medical science extended the life of diabetic individuals, long term effects of the disease on every system in the body begain to show.

Older individuals trying to relate a family medical history may recall a parent or grandparent died of heart disease or kidney disease and these may have been the result of undiagnosed diabetes back in the day. On the otherhand, way back when, before antibiotics and with wars (when life expectency was less than 65 years), diabetes may not have manifested. My point is this: diabetes may not be spreading in the population, it may have been with us all along.

I know discussion on the topic was closed yesterday, but had to address the correction...then I got carried away I guess!

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Guru

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#1

Re: ADA Alert Day: High Glucose in the blood

03/24/2010 9:33 AM

Thanks for your comment, Guest. It definitely adds another dimension to the post, which is still open here. I will update it with the hyperglycemia correction.

Admittedly, I usually shy away from writing about medical issues as its very easy to get something wrong or not get detailed enough if you're not in the medical field (I'm not).

However, I think diabetes awareness is a very important issue as it affects some of my loved ones personally -- as I'm sure it does many others as well. I appreciate comments like yours that fill in the gaps and catches inaccuracies -- knowledgeable people are part of the reason CR4 is such a great place.

Thanks again!

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Anonymous Poster
#2
In reply to #1

Re: ADA Alert Day: High Glucose in the blood

03/24/2010 2:53 PM

Guest here, again.

In the 1960's it was rare to know someone with diabetes. In the 1970's you knew of someone with diabetes. In the 1980's you knew someone with diabetes. In the 1990's you were related (by marriage) to someone with diabetes. By the start of the 21st century, you were related to someone with diabetes. In this decade, you have a 20 to 25% chance of developing diabetes. Also to come, there will be a 50-50 chance your children will be diabetic. And at an early age.

Sharkles, it's a disease that affects everyone and our progeny. Since our metabolisms aren't keeping up with glucose intake or production naturally, an engineering solution is necessary. Over 25 million Americans are at or close to a diagnosis of diabetes. Whatever solutions we come up with will not be spent on a few but may be necessary for long term survival.

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#3
In reply to #2

Re: ADA Alert Day: High Glucose in the blood

03/25/2010 1:33 AM

Guest,

I appreciate your input on the topic. I do disagree with your statement "our metabolisms aren't keeping up with glucose intake or production naturally, an engineering solution is necessary." though. Our metabolism is highly influenced by the composition of our diet. Our ancestors did not consume the highly processed foods and carbohydrates that are common in the majority of diets today.

What has changed in the last 40 years? Dietary fat was deemed to be dangerous, carbohydrate intake increased, and low and behold there is has been a steady increase in obesity rates and diabetes since then. There are many documented cases of isolated societies (island, remote jungle areas, etc.) where diabetes, heart disease and other diseases of civilization are vitually unheard of.....along comes civilization and within a generation or so, diabetes, heart disease, etc. start showing up in similar rates to the more civilized world.

I guess I would rather see a change to a lower carbohydrate diet as opposed to an engineering solution. Now if by 'engineering solution' you mean a way to inexpensively produce and distribute low carbohydrate foods, then I would agree.

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Anonymous Poster
#5
In reply to #3

Re: ADA Alert Day: High Glucose in the blood

03/26/2010 6:18 AM

About time to reduce intake of Junk Food by 90% and replace it with Home-cook Organic Food. Prevention is still the best antidote, thus no need to seek irrelevant cure then.

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#6
In reply to #5

Re: ADA Alert Day: High Glucose in the blood

03/26/2010 12:38 PM

? Are you implying that "Junk food" is inorganic?

Funny thing about organic food is that in order to provide fertilizer they must use substantial amounts of manure, and not chicken manure as that is not considered acceptable under organic grown definition. So they typically use manure from source typically cattle, maybe pig, both of which comprise a primary source of E coli and other infectious bacteria. Almost every case of E coli infections has arisen because the product was contaminated by fecal material from humans or cattle. Additionally, many of the cases related to liquids were caused by the product not being homogenized, in order to maintain organic "healthy" quality.

Believe it or not, coming from a farming family I already know that behind the japanese, McDonalds has some of the highest produce quality standards you can find. whereas organic growers typically produce foods of poor quality control on purpose to achive the " natural" quality buyer expect, and only have to make sure not to use certain pesticide/herbicides and fertilizers (some are deemed acceptable, though from a chemical stand point there is not real distinction except in quality control of the product used).

In addition, the manures organic acids tend to form chelating agents that mobilize orders of magnitude greate concentrations of resident heavy metals from the naturally occurring minerals in the soils and the plants will bio-accumulate these heavy metals (This is actually a method we use to remediate metals contaminated soils). So if you live in an area where certain metals minerals occur, which are generally found in highly insoluble sulfide forms, the organic agriculture process can contribute to oxidate (increasing mobility), and then chelation (greatly further increasing mobility) allowing for a very high level of bio accumulation of metals, e.g. lead or mercury.

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#7
In reply to #6

Re: ADA Alert Day: High Glucose in the blood

03/26/2010 9:05 PM

A few years I read an article about E coli and foods. Grass is the natural diet of cattle, not grain. Of course the cattle industry mostly utilize grains to fatten and grow their cattle. A down side of this is that it increases the E coli (O 157:H7) in the manure.

Here's a quote from the article "A number of studies have shown that switching cattle from grains to roughage (grass or hay) drastically reduces the amount of E. coli O157:H7 in their manure". Also here is a link to the article http://www.proteinpower.com/drmike/good-eating/another-reason-to-eat-grass-fed-beef/

With all that in mind, I do not know if in order to be "certified" organic producers have to use manure from grass fed cows or not. I, also, am not aware if there are even organic growers who attempt to do so.

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#4
In reply to #2

Re: ADA Alert Day: High Glucose in the blood

03/25/2010 12:16 PM

25 million close to a diagnostic condition of diabetes divided by 300 million does not equal 50/50 chance of childhood diabetes, especially since it is so prevalent amongst older persons in our society. However, even if it was a equal distribution through society it would still be less than 10% probability in childhood.

So the question is how do you come up with a probability of 20% to 25% of adults developing diabetes and 50% chance of children developing diabetes. I think ther is something fishy about your supposed statistics.

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