As long as the joint is still an AWS pre-qualified weld, you can weld as required in the WPS. If it is outside of the pre-qualified parameters, the weld must be qualified with approved AWS testing (Found in AWS D1.1 / D1.3, etc. if compliance to AWS is required). I believe API compliance criteria is similar.
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"Stepping up to the plate" is not enough, you have to swing to get a hit!