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Preventive Medicine: Antimicrobial Technology Reduces Secondary Infections

06/20/2007 2:19 PM

I am looking for feedback on the following article:

You have a serious illness. The good news is that it was diagnosed early and is treatable. You have just gone through a battery of treatments and your immune system has been compromised. You go to your hospital room and lay down on the bed to sleep. Above your head is a fluorescent bed light that quietly hums while you to sleep. What you don't know is that last week, the light bulb in the bed light burned out and was replaced by the hospital maintenance worker, who had a tuna fish sandwich for lunch. He inadvertently wiped some mayonnaise on the bulb, which is now festering with bacteria. The bacteria are multiplying and spilling out of the light fixture and on to your bed. Unfortunately for you, your pillow is now infected with bacteria, and you are in no position to fight it.

When you wake up, your family is there to see you. You get out of bed by pulling on the side rails on the bed that your children were just hanging on. You go to the bathroom door and open it, move into the bathroom, and hold on to the grab bar for support. When you are finished, you push open the bathroom door and return to your bed. You rub your eyes and eat your lunch, and chat with your family. You feel pretty good.

Unfortunately, chances are you have been infected with any number of secondary microbes that can range from staph, to pink eye, to common cold, any of which can severely complicate your current condition. This entire scenario would have been different if the hospital had taken advantage of the antimicrobial technology that is available to it today. The light fixture, the bed frame, the doorknob, the grab bar, and the bathroom door push plate all should have been coated with active antimicrobial finishes. Real life and death scenarios just like this affect millions of patients each year, and many of those lives could be saved with this technology.

My profession is metal finishing and powder coating. One of the areas I have been concentrating on for the last four years is antimicrobial finishes. I have been working with them and promoting their use for all applications that involve medical products, hospitals, food service, schools and universities, mass transit, and high pedestrian traffic public locations, with little to no success to date. The technology is proven, and the cost is insignificant compared to the standard material used (stainless steel) and the tangential cost of secondary infection. This technology is readily available, and can be applied to practically any metal or MDF product.

For many years, stainless steel has been the material of choice for product requiring a sterile surface. Stainless steel is a low carbon steel alloy that is extremely resistant to corrosion and oxidation. This makes it ideal for applications that require constant cleaning with strong antiseptic cleaners and sterilizing chemicals. Unfortunately, stainless steel has two major drawbacks; it is not actively resistant to bacterial growth, and it is very expensive. Also, a stainless steel grab bar in a bathroom must still be thoroughly cleaned and disinfected to kill the bacteria on its surface. If an area is missed, the bacteria remain. Only an active antimicrobial surface can remain free of bacteria indefinitely, and only an antimicrobial coating or component can provide that surface. A less expensive carbon steel that has been powder coated with an antimicrobial material will still hold up to the chemical cleaning, but will cost less and be considerably more effective in reducing the chances of secondary infection.

There are several different types of antimicrobial coatings currently available. Some are based on the natural neutralizing effect silver has on bacteria, which goes back the early use of silverware and silver drinking vessels. Some coatings use aggressive geometry to pierce the bacterial cell membranes. Some manufactured products incorporate chemicals such as chlorine to kill germs and bacteria. The idea is to provide a surface environment that is incompatible with the existence and reproduction of microorganisms, which will remain that way for the life of the product. In most cases, there is a body of evidence to suggest that none of these methods result in a modified or mutated strain of resistant or adaptive organism, and all methods have data promoting their effectiveness.

I understand that organizations like the Gates Foundation, who are fighting the good fight against sickness and disease, are building new facilities to carry them through the next decade. I have to ask, "are they have considered using antimicrobial coatings and materials for their table tops, hand rails, door knobs, push plates, grab bars in bathrooms, elevators, wall plates, etc. to minimize the spread of common illnesses?" Does your organization? Does the government when they build a new airport terminal? A new school? A new hospital wing? Will they spend their money on traditional stainless steel products or will they use the 21st century technology that is available today?

So, the next time you run your hand along a railing in an airport, or push open a door at a rest stop on the highway, or step on a scale at your doctors office in bare feet, think about who touched it last, and what they might have left for you. And know that if it were coated with an active anti-microbial coating, or was made with antimicrobial materials, you wouldn't have to worry. And if you or someone you know is in the scenario described above, ask yourself how important this technology can be in your life.

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Anonymous Poster
#1

Re: Preventive Medicine: Using Antimicrobial Technology to Reduce Secondary Infectio

06/20/2007 11:15 PM

Plain old Salt and UV radiation from the Sun are two natural ways to kil the little buggers.

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Anonymous Poster
#2

Re: Preventive Medicine: Using Antimicrobial Technology to Reduce Secondary Infectio

06/21/2007 6:16 AM

One question is how do you keep bacteria from evolving into forms resistant to the treated surfaces?

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#4
In reply to #2

Re: Preventive Medicine: Using Antimicrobial Technology to Reduce Secondary Infectio

06/21/2007 8:35 AM

The technology based on silver is actually over a thousand years old. The Egyptians used silver in cups and containers to handle food. Silverware and silver lined mugs and cups have been in use for many years, as silver has a natural ability to penetrate the cell membranes of microorganisms and disrupt metabolism and reproduction. Because this is a natural phenomena, built up resistance has not evolved as is it does for antibiotics and other synthetic materials. For more information, you can contact AGION Technologies directly. My contact there is Tammy at tpate@agion-tech.com

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#3

Re: Preventive Medicine: Using Antimicrobial Technology to Reduce Secondary Infectio

06/21/2007 8:35 AM

Can someone describe or direct me to a site that gives some nfo on these active atibacterial coatings. I have been in the Biotech industry for over 18 years and have not heard of them.

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#5
In reply to #3

Re: Preventive Medicine: Using Antimicrobial Technology to Reduce Secondary Infectio

06/21/2007 10:25 AM

Mike:

The powder coating companies I deal with have antimicrobial powders that use technology from different companies. Dupont uses Agion, Spraylat uses SilverSan, and there are others. The Agion website is www.agion-tech.com and they offer several types of antimicrobial materials. I read an article about an anitmicrobial additive that was based on sharp pointy particles. This research was from MIT, and I tried to get more information from the professor in charge of the project but could not get a response.

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#6

Re: Preventive Medicine: Antimicrobial Technology Reduces Secondary Infections

06/21/2007 10:29 AM

Great article, very informative. How abrasion resistant are these coatings? Obviously many surfaces such as stairway and escalator handrails, door pulls and knobs, elevator buttons and touch plates and so on would be ideal candidates for these anti microbial surface treatments. Will they still be effective after millions of touches?

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#8
In reply to #6

Re: Preventive Medicine: Antimicrobial Technology Reduces Secondary Infections

06/21/2007 1:06 PM

This is my understanding of how the technology works, however I do not speak for the product manufacturers. As someone famous once said..."I could be wrong, but..."

The silver nitrate is contained inside a ceramic zeolite container, which allows steady but controlled release of the silver ions to the surface of the coating. The mechanism of release is friction or abrasion combined with moisture. The zeolite containers are not nano, but are very small and homogeneously dispersed throughout the coating material. The coating, in my case powder coating, is applied to an average of 3 to 5 mils (.003 to .005 inch). A standard Taber test done by one of my customers, a railing manufacturer, yielded over 7,000 rubs. The met or exceeded their best finish. The point is, theoretically speaking, as long as there is coating, there is protection. Also, the antimicrobial material can be added to resin and cast, molded, or extruded, giving the same antimicrobial property to a variety of finished products, such as stairway and escalator handrails, door pulls and knobs, elevator buttons and touch plates. Hope this helps.

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Anonymous Poster
#7

Re: Preventive Medicine: Antimicrobial Technology Reduces Secondary Infections

06/21/2007 11:47 AM

Do you know if there is some of these products that are also corrosion protecting.

We have an application were we want to sterilize metal racks into an autoclave that is functionnig with high corrosive pure water grade ( Reverse osmosis water).<

We normally use passivated or electropolished 316L SS.

Is there a poosible alternative with these.

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#9
In reply to #7

Re: Preventive Medicine: Antimicrobial Technology Reduces Secondary Infections

06/21/2007 1:15 PM

We often powder coat carbon steel with corrosive resistant coatings that are used in highly corrosive environments. We coat over stainless steel as well. As far as coating a product with a corrosive resistant antimicrobial, I do not see why that would be a problem. It also my understanding that the antimicrobial material will withstand considerable temperatures without breaking down. If the look of stainless is required, the antimicrobial coating is available in clear as well as colored flavors.

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Anonymous Poster
#10
In reply to #9

Re: Preventive Medicine: Antimicrobial Technology Reduces Secondary Infections

06/21/2007 2:29 PM

Hi

Do you think aluminium racks could be a good alternative for sterilization in an autoclave with ultra pure water?. With or without corrosive resistant coating??

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#11
In reply to #10

Re: Preventive Medicine: Antimicrobial Technology Reduces Secondary Infections

06/21/2007 2:40 PM

I am neither a metallurgist nor a doctor, but I do not see why aluminum would not work, assuming there is no need for structural integrity. If the aluminum is of sufficient size it will withstand many heatings but may eventually warp and fail. Nylon may also work.

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Anonymous Poster
#12
In reply to #11

Re: Preventive Medicine: Antimicrobial Technology Reduces Secondary Infections

06/21/2007 5:08 PM

Thank you very much.

Everybody here is paranoiac about the corrosive effect that ultra pure water may have on aluminum racks at long term usage.

I think i'll do some deeper researches on the subjet but your thoughts about it are the same as mine.

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Anonymous Poster
#13

Re: Preventive Medicine: Antimicrobial Technology Reduces Secondary Infections

06/21/2007 9:04 PM

If your condition is such that substantial vulnerability exists,
you will be placed in isolation. In the scenario you pose, coating of
surfaces would provide so small a reduction of exposure as to be
a waste of resources better deployed elsewhere

Anti-microbiotic coatings are either toxic, and/or not broad spectrum enough,
and/or not durable enough and/or not persistant enough to be worth the effort.

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#14

Re: Preventive Medicine: Antimicrobial Technology Reduces Secondary Infections

06/22/2007 4:34 AM

I have no idea who to contact, but, have you approached the National Health Service in the United Kingdom. We have terrible problems at the moment with MRSA (Methicillin-Resistant Staphylococcus Aureus) and CD (Clostridium Difficile). These are both illnesses which you are really likely to get if you go into hospital for something else (often less serious).

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