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Join Date: Jun 2014
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Can The Hippocampus In A Mouse, Human Ever Be Mapped

06/10/2014 10:01 PM

Can the hippocampus in chimp, or human be mapped, and what would be the best way to do it.
The yet to be built INUMAC FMRI machine will be able to see 0.1 mm into the brain, which is around 1000 neurons, there are microscopes that have magnified up to 700 neurons in a mouse's hippocampus, at Stanford University,
but this was done
invasively, if you were going to do it in a chimps brain, you would need to be able to
get to the hippocampus non-invasively.
Because the hippocampus in a chimps brain is encased by one and a half, to two inches of brain tissue.
Then to see the electro and chemical signals traveling through the neurons, you would have to use the gene
therapy approach, using a green florescent protein that stimulates when the neuron fired.
When the neuron fired calcium ions naturally flood the cell, this triggers the protein, and the neurons glow bright green, so researchers can see the activity happening in real time,
like in a movie clip, with the neurons.
So when the mouse is in it's arena researchers at Stanford can tell which part of the arena the mouse is in by looking at which groups of neurons fire, and which do not.
So with the INUMAC FMRI machine, combined with MEG, and using the gene therapy approach, by
injecting the green florescent protein into the chimps brain to see the neurons
communicating with each other, is this the best way to attempt to try and map a chimps Hippocampus.
Or is their a better way to approach mapping the chimps Hippocampus.
If the were a lot of people working on mapping the neurons, say 5000 people associating what groups
of neurons fire with which memory could this be the best way to map the
hippocampus.
Would it take maybe more people, if their are 100,000 neurons per cubic millimeter.
Also how many neurons do you estimate their are in the hippocampus.

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Guru

Join Date: Jun 2013
Location: Central Canada
Posts: 677
Good Answers: 28
#1

Re: Can The Hippocampus In A Mouse, Human Ever Be Mapped

06/11/2014 2:38 PM

Your questions might be better served by posting them in a neuro science research site, if such exists.

Perhaps http://www.sfn.org/

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