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Participant

Join Date: Sep 2014
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Miscible Polyelektrolytes

10/04/2014 8:07 AM

Dear engineers and scientists,

How would one determine whether or not an interpolyelectrolyte complex of two polyelectrolytes can be produced by precipitation?

A particular example: Nafion and Eudragit.

Best regards,

M.H.

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Guru

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#1

Re: miscible polyelektrolytes

10/04/2014 10:36 AM

By trial and error.

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#3
In reply to #1

Re: miscible polyelektrolytes

10/05/2014 2:41 AM

Amazing that you have an opinion on everything I can't wait to see what you have to say in response to my questions

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#4
In reply to #3

Re: miscible polyelektrolytes

10/05/2014 12:20 PM

What questions?

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#5
In reply to #4

Re: miscible polyelektrolytes

10/05/2014 5:05 PM

One question for the group I have is rather narrow in scope. Does anyone have experience with Sim Sci's program pipe phase? I am finding it to be quite unstable. If you make a simple change, like asking for different units of measure in output, the program suddenly will not converge. The PFD output it does not show flow rates or elevations ... Which is Exactly what you would be wanting to know when you run the program. I find this to be rather unbelievable. So, it will be interesting to see what Lyn has to say about this.

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#6
In reply to #5

Re: miscible polyelektrolytes

10/06/2014 12:00 AM

I would contact the support team, and check for software updates....

http://software.invensys.com/support/simsci/

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#7
In reply to #6

Re: miscible polyelektrolytes

10/06/2014 1:56 AM

Sad to say, after multiple requests from SimSci support,,, for some reason I got John from Utah every time I called... And he admits to not knowing details of PipePhase,,,, I got an official written reply that the PFD can not show elevation, or flows (!). You have to look at the output, which is over 2,000 pages long. Keeping track of the elevation of every leg in a complex network,,, the PFD can not do it. yOU better do it, or the model will not run if you have two lines joining that are not at the same elevation. Wondering if the group has had the same frustration, and if there's a better software product, like Fathom.

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#8
In reply to #7

Re: miscible polyelektrolytes

10/06/2014 12:54 PM

I would start a new thread asking this question....somebody knows....

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#2

Re: miscible polyelektrolytes

10/04/2014 12:20 PM

"The solubility of proteins in aqueous buffers depends on the distribution of hydrophilic and hydrophobic amino acid residues on the protein's surface. Hydrophobic residues predominantly occur in the globular protein core, but some exist in patches on the surface. Proteins that have high hydrophobic amino acid content on the surface have low solubility in an aqueous solvent. Charged and polar surface residues interact with ionic groups in the solvent and increase the solubility of a protein. Knowledge of a protein's amino acid composition will aid in determining an ideal precipitation solvent and methods."

http://en.wikipedia.org/wiki/Protein_precipitation

http://www.permapure.com/support/all-about-nafion-and-faq/

http://www.ncbi.nlm.nih.gov/pubmed/23102011

http://eudragit.evonik.com/product/eudragit/en/products-services/eudragit-products/enteric-formulations/pages/default.aspx

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