..."They explain that their previous research has shown that high blood sugar causes an overproduction of a protein called TXNIP - which is increased within beta cells in response to diabetes. Too much TXNIP in pancreatic beta cells leads to their deaths, stopping the body's efforts to produce insulin and further promoting diabetes.
However, in animal models, the team has found that verapamil - used to treat high blood pressure, irregular heartbeat and migraine headaches - lowers TXNIP levels in beta cells.
In fact, in mice with established diabetes and blood sugars over 300 mg/dL, verapamil "eradicated" the disease."...
"Now, the UAB researchers have received a 3-year, $2.1 million grant from JDRF - the largest charitable supporter of type 1 diabetes research - to conduct a clinical trial in 2015 in humans."
..."A unique feature of this trial is that it will not include the use of any immunosuppressive or immune modulatory medications, which carry severe side effects and are used in most type 1 diabetes trials.
"This trial is based on a well-known blood pressure medication that has been used for more than 30 years and is unlikely to have any severe side effects," adds Dr. Shalev, who also notes that their study is backed by a wealth of data in different mouse models and human islets."...
http://www.medicalnewstoday.com/articles/285033.php
Possible Cure for Diabetes
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