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Nanoparticles are great for biomedical applications like delivering drugs efficiently and attaching mostly-inert fluorescent labels to molecules of interest, but they also pass through our skin and lungs, and may be more toxic than larger particles of the same substance. We don't yet know a lot about the health effects of nanoparticles, yet people exposed to them at work are likely to receive relatively large doses. Are you concerned about nanoparticle safety? What do you say when a less-scientifically-inclined acquaintance asks if they should be worried about the nanoparticles in their sunscreen?
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