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Alexander Fleming accidently discovered penicillin in 1928;
85 years later antibiotics are losing their effectiveness and with a lack of
new antibiotics in the pharmaceutical pipeline health professionals are
starting to get nervous.

Image Credit:
Living Green Magazine
What is an
antibiotic?
The term antibiotic literally means "against life"; in
this case, against microbes. The most commonly used antibiotics are
antibacterials but there are also antivirals, antifungals, and antiparasitics.
Some of these drugs are considered broad-spectrum, which means they are
effective against many organisms.

Image Credit: TextbookofBacteriology.net
Before antibiotics, 90% of children with bacterial
meningitis died, and those who survived were often left with severe and lasting
disabilities. Other serious infections, from tuberculosis to pneumonia to
whooping cough, were caused by aggressive bacteria that reproduced with
extraordinary speed and led to serious illness or death. Many of these and
other deadly childhood diseases are now easily treatable with antibiotics
Antibiotics on the
Market
Penicillin (technically a mold) became widely available
to the general public by the mid-to late 1940s. This success started a race to
produce other antibiotics and now there are dozens on the market for doctors to
choose from, which doctors prescribe at a rate of 150 million a year.

Image Credit:
Textbookofbacteriology.net
The rate of prescription writing has started to decrease
due to a phenomenon known as antibiotic resistance. Antibiotic resistance is
the ability of a microorganism to withstand the effects of an antibiotic. It
evolved via natural selection through random mutation, but it could also be
engineered by applying an evolutionary stress on a population. This strain has
produced Superbugs, also known as multi-drug resistant bacterium.
Superbugs and other antibiotic
resistant bacteria are a very real health concern. More and more infections
are becoming difficult to treat. Professor Dame Sally Davies said that the real
"apocalyptic scenario" will be within a couple of decades. People will die from
infections because there will be no new antibiotics. The two major causes of
this potential scenario are the lack of new antibiotics in the pharmaceutical
pipeline and the fact that the drugs are not being effectively used.
Examples of this resistance can be seen in many types of
infections. There is only one effective treatment left of gonorrhea; a
multi-antibiotic resistant tuberculosis kills 150,000 people around the world
each year; and Staphylococcal (the bacteria that causes strep throat among
other things) and urinary tract infections are now resistant to penicillin.
Perhaps the most media recognized multi-antibiotic resistant infection is MRSA,
a skin infection which is increasingly prevalent (and deadly), especially in
healthcare facilities.

Strep Throat. Image
Credit: Wellness Online
Doctors are becoming more careful about prescribing these
medications only when necessary. One recent survey of office-based physicians,
published in The Journal of the American Medical Association in 2002, showed
that doctors lowered the number of antibiotic prescriptions they prescribed for
children with common respiratory infections by about 40% during the 1990s.
Unless pharmaceutical companies start focusing on
developing antibiotics instead of high revenue generating drugs like those for
chronic diseases, we will be taking a big step back in medicine. Aliments that
were easily treated with antibiotics will once again be dangerous and/or
deadly.
Resources
The
History of Antibiotics
Expert
warning: Resistance to antibiotics to be apocalypti
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