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Genetics, Disease and Organ Removal

06/19/2006 2:21 PM

Here's the scenario: Many of your relatives have died of a rare and always lethal stomach cancer. After genetic testing, you find that you are 70% likely to develop the same cancer. What would you do? Would you shrug it off and hope that you are in the safe 30% or hope that the somewhat nascent technology that extrapolated the probability is wrong? Would you radically alter your diet and try find other ways to eliminate risk factors, hoping that this would be enough to stall a hereditary disease? Or would you take the drastic step of having your stomach removed to eliminate the risk? That's what 11 cousins chose to do.

Risky or even more risky? Stupid or genius? What does this hold for the future?

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#1

Some Thoughts

06/19/2006 3:54 PM

Well ignoring 70% odds is like leaving your convertible with the top down all day after the weatherman declares a 70% chance of rain. Generally, this data is developed from family history, so it is all but impossible to ignore if you have a large number of family members succumbing to cancer!

In the case you cited, the issue is with something called oncogenes. These are cells that contain some form of hereditary genetic miscode or damage that predisposes those cells to undergo a cellular transformation to a cancerous cell (i.e., a cell that becomes immortal). In order for cancer to take root a cell must be sufficiently mutated so as to undermine all of its natural defense mechanisms (apoptosis is the big one) and short circuit the cell's life cycle so that it spends nearly all of its time in the mitosis phase of its life cycle. This is why cancer cells grow so aggressively, because they are constantly dividing and their metabolic uptake is very high (that is why PET scans work so well).

Just because you have oncogenes does not predispose you to cancer, but it does up the odds. Therefore, it is prudent to reduce any risk factors that you may have. So I am a fan of improving diet and exercise as a means to reduce risk via a healthy lifestyle. Beware of the homeopathic route, but there are many common-sense things you can do to help yourself. It is also good to work on your mental health. Negative emotions will alter the body's chemical and hormonal balance.

In the case of the 11 siblings, the odds were so great that the surgical route had merit. In fact, pathology found tumors in some of the tissue samples, if memory serves. That tells me it was a prudent move. For me, I would take the warning seriously and probably undergo the surgery and consider whatever lifestyle changes I could that would further improve the odds, but that is because I love life and want as much out of it as I can get.

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#2

Genetic disease?

06/20/2006 1:39 AM

Genetic disease? Accepting that could be true, that a disease appears each generation's life time and as a consequence was associated as a genetic perpetual defect, that being the cause of all bed things followed by this fact. If so, why the specialized research it's not focused on the prevention, by taking over the body's immunologic tasks which would widen the stomach's possibilities of fighting against the "enemies" together with its own specialized "doctors" and avoid him falling into so called sustainer of the cancerous cells development? I think that first we have to re-establish the body's acido-basic balance and than to see who's trying to continue to harm the stomach's guardians which are well aware about their "inmates' behaviors"; I've tried personally this method and all I have to say is that it works. Always I considered that we possess a genetic code as an ideal human's info construction code, based on many known or unknown yet algorithms, which can suffer alterations because many influential factors like different radiations, chemical, bio-energetic, etc. sources. I think the many modern big 'questions' could be solved in as simplest way as possible by a little effort. Even (not necessary) we would eliminate the stomach 70% and suppose that the genetic code 'army' will take care to rebuild the missing 70%, but my question is if it would happen with or without the 'genetic disease' again? My philosophy is that it's possible to obtain the success step by step, as I've enounced above, and than to continue the research.

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#3

No stomach for it

06/20/2006 10:31 AM

Sounds like they had a really tough decision to make. Hope the researchers are correct in their assessment.

On the other hand, it is interesting to know that one can survive without a stomach.

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