It would help very much if you inform about the mineral powder you're talking about, expected composition, hardness, and volume you'd expect to work with over time.
You'd be surprised with the several different ways to break particles in a manual or semi-automatic way (I used to do a lot of it during my days in a welding lab at university). But it may not be feasable depending on your process parameters.
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Our cryogenic ball-mill should mill it down to that size. The time in mill (#hours) required to reduce it from 40u to <100nm is to be determined for titanium dioxide silver chloride. You could do a characterization run where we pull a sample out say every hour or 3-5-8 hours, and put in an in-house scanning electron microscope that can confirm post-milling particle size. A run like this would be about 1Kg (2lbs) of powder. Then we could proceed from there.