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Medical Animation and Mechanism of Action (MOA)

08/02/2009 8:29 AM

Recently a fiend wanted advice regarding choosing the career in the 'Medical animation'.

He also mentioned his assignment includes 'Mechanism of action'.

Wikepedia,the encyclopedia, describes the term 'Mechanism of action' as, "the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor. For example, the mechanism of action of aspirin involves irreversible inhibition of the enzyme cyclooxygenase, which suppresses the production of prostaglandis and thromboxanes thereby reducing pain and inflammation.".

Though CR4 forum discusses on Engineering, request views about the career Medical animation,specifically on "How MOA is related to Medical animation?". Thanks.

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#1

Re: Medical Animation and Mechanism of Action (MOA)

08/03/2009 12:44 AM

Medical animation is useful to explain to the patient what happens in the course of a treatment. It is more relevant to implanted biomedical devices. Please see the animations here:

http://www.youtube.com/watch?v=8lwd8SrWqh0

http://www.youtube.com/watch?v=ujufwf3d6H8&feature=related

http://www.youtube.com/watch?v=9FPapBbbS4o&feature=fvw

bioramani

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#3
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Re: Medical Animation and Mechanism of Action (MOA)

08/03/2009 6:02 AM

Thank you for the information. I could gather some more details which I wish to share. The scope covers mechanism of absorption, distribution, metabolism and excretion of drug in human body. Medical animation acts as a visual aid for pharmaceutical product managers and marketing directors to enable their target audience to visualize and understand how a drug works, interacts with the receptors in body and thus allows them to make a decision on the future potential of drug. The complex mechanism of drug metabolism and unique drug delivery system are brought into life with medical animation. Medical animation serves as a complete package for conceptualizing: Absorption - route of administration of drug -> Distribution - Movement to reach target organ -> Metabolism- Chemical modification into metabolites -> Excretion- Elimination of metabolites

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#2

Re: Medical Animation and Mechanism of Action (MOA)

08/03/2009 1:31 AM

I guess you answered your own question.

The MOA for drug actions which you cited from wiki can also be animated - this would be to some extent an "artist's concept" of how to visually represent cell receptors and so on.

I have seen some enzyme or 3d molecular representations that are quite good, showing how the protein folds for example, to give a three dimensional configuration that fits a receptor very specifically. I'm pretty sure there's shareware or freeware available for chemical modeling. The new animator would do well to look for this open source software, for a start, if he is going to animate chemical mechanisms of action.

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