By Googling "air pressure altitude" you can get some tables that give the air pressure at various altitudes. For instance, at 35,000 feet (a common cruising altitude), the airpressure is 3.37 psia. Compared to 14.68 psia atmospheric (if the cabin is pressurized to full atmospheric), this is a difference of 11.31 psi. The higher pressure is internal to the cylinder, which is the favorable direction.
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