Alzheimer's Cure?

Interesting info. Thanks for posting it.

Thanks Artsmith for the additional info.

You're very welcome. Suffice it to say, I have a vested interest in reading and learning about this subject.

There are some interesting developments in the research happening now, hopefully leading to effective treatments in the near future. An important aspect of the disease that has not been targeted in the past is the misfolding of the protein 'tau' causing the 'tangles' effect.

Two promising therapies are discussed in recent work: the immunization approach (which was less successful with the amyloid beta plaques) is showing a lot of promise in animal models, as in this research at NYU promising clinical trials in the near future.

Secondly, there is research on therapies using the "chaperone" proteins involved in regulating protein folding. A group of molecular chaperones called "heat shock proteins" are involved in regulating tau. When the HSP's are induced or overexpressed they can counteract the progression of the disease.

There are some safe and nontoxic means of inducing HSP-70, notably resveratrol, which is unlikely to cause any harm afaik and is widely available and GRAS. The Japanese have been researching a naturally-derived drug geranylgeranylacetone, which is also reported nontoxic and a reliable inducer of HSP-70 and has shown benefits in a number of conditions (lots of publications). It's marketed as a treatment for stomach ulcers in Japan, under the name Teprenone.

There is also some research going on at USF, suggesting that a two stage therapy involving induction of HSP-70 followed by modification of its ATPase activity, would produce best results. There may be clinical trials coming out of these researches as well, you may find something helpful on their webpages.

All my life I have lived in the coconut rich states of South India. Coconut is a daily ingredient in virtually every meal. (Both vegetarian and non vegetarian). I have worked long at a federal medical research facility specializing in neuro and cardiac sciences in Kerala, perhaps the state with the maximum consumption of coconut.

While the number nut cases (could not resist that) and senile dementia were about normal, Alzeimer's was quite rare.

We did not do any active study of this anyway.

There are some reports that curcumin (active principle of turmeric, a spice also in daily use in India) also reduces Altzeimer's.

Bioramani

Hello,

Thanks for posting info about curcumin and its potential to reduce Altzeimer's

There is way to consume curcumin, by mixing with coconut milk.

Mixing curcumin with coconut milk, helps absorption of curcumin.

Regards

Madhav Chowdhary

Pune

I don't know about coconut, but I do know something else you can try. My best friend's wife works at Genentech in Silicon Valley. She is a genetic researcher working on a cure for Alzheimer's, Lou Gerrig's diosease and Parkinson's. All these diseases have similarities. I know that for Alz they discovered that nicotine can halt the onset and reverse the damage caused if you catch it early and start aministering the drug. This was due to the realization that smokers don't get Alz. I'm not talking out of my ass here. This woman has sliced more frozen rat brain(for slides) than you butcher has seen beef. I have talked to her extensively about this and evidently, they are trying to synthesize a drug that isn't as harmful as nicotine to dose new onset Alz patients with. As of now, I know that you can give any kind of nicotine gum twice a day, morning and evening(9am-9pm) on the lowest dose. (nicotine gum comes in different strengths) VERY IMPORTANT>>You have to tell the person to only chew it until their mouth starts to tingle, then spit it out. You can't chew it like bubble gum all day long, you will overdose yourself. Within a week or two, overdose can cause diarrhea, indigestion, insomnia and can also cause tiny muscle spasms sometimes, but only in the beginning. You really have to spit it out as soon as your mouth starts to tingle. What it does is stimulate the neurons in the synapses of your brain and keeps them healthy and working. You can't use a patch, because it's a steady release, not the spike you get from the gum. You have to have the "spike" to stimulate the neurons. It does eventually become habit-forming, but I would think it's preferable to Alz. At this time I have two friends with older relative with Alz chewing the gum, (they were diagnosed it very, very early) their condition has not worsened, and so far they have shown no further signs of memory loss. We are keeping our fingers crossed.

sorry to here about your families misfortune. don't waste your time on this site. i don't think anyone here can help you.

It's not so common here in the Philippines this disease. Never heard of someone having this kind of disease here, though there might be. I do not know.