Inducing Allergies

Like every disease that is studied, there are many experimental models to induce allergy in animals. Different animals are more or less susceptible under specific models, but the basic approach - inducing sensitivity by some method of exposure to the allergen, with or without an adjuvant, is simple and is equally applicable to humans as to other species. It is simply an acceleration of the usual process by which we ordinarily become allergic to one thing or another.

More difficult models, involving genetic manipulation in fast breeding species (usually mice) or selection and breeding of a genetically sensitive population for experimental purposes, obviously would not be readily applied to humans.

How easy or how difficult it is to produce an allergy, varies depending on the model and the species involved. For example this model of dust mite lung allergy in sheep simply requires an inoculation with dust mites by injection. This produced the desired allergy condition in 50-60% of the sheep.

In another example, a different route is used with guinea pigs to induce allergic conjunctivitis, by direct physical exposure to the allergen. IL-4 is a naturally occurring cytokine which is overproduced in case of allergy, which might be used as 'adjuvant' in some models, although it conferred no advantage in this one.

This makes the point, that physical exposure to an allergen is how we get allergies in the first place, without any malicious intent as implied in your question. The first example (sheep) also makes the point, that sensitivity varies. In case of malice, there are without doubt, more certain means of harm.

More could be said about induction of specific allergies, but you would have to elaborate on the specific case or reason for your question.