Lyn is right, you can go Faraday Cage, but other less costly options may be effective if properly designed for the specific problem in question - you need to provide more details.
In order to be an effective obstacle to an incoming signal, the design spec of conductive elements in a shielding device is that the length must be at least 1/10 of the wavelength of the signal in question. So first tell us, what is the frequency of the signal in question, or the range of frequencies you want to block. There are numerous shielding products on the market, including conductive paints and fabrics, and depending on the metals or conductive materials used and the design, different products are also best for specific frequency ranges. What is the size of the area that you want to isolate? Is the problem signal directional? You need to provide these details too, for appropriate solutions to be proposed.