I was thinking about submersible vessels that can go down thousands of feet below the ocean's surface. It seems to me that, as long as you stay in the vessel and the environmental system of the vessel maintains a strict composition and pressure of atmosphere at sea level, you would be just fine.
However, I remember that (at least some of) the bathyspheres and bathyscaphes used mixtures of helium and oxygen (Jaques Cousteau - National Geographic).
What was their purpose for using that mixture?
Mike