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Updated Gamma Knife Question, Thought of Something New.

06/17/2014 7:14 PM

I want to see if the Gamma Knife can be upgrade, modified, and push to its maximum potential limit to be able to eliminate neurons on the micron scale.
The way the Gamma Knife works is that a person is put into the Gamma Knife machine head first.
Gamma Knife uses many beams of radiation from multiple angles to target one specific area in the brain.
Alone, each beam is too weak to damage the healthy tissue through which the beams travel.
Where the beams meet, however, the combined radiation is strong enough to treat the area.
The neurosurgeon will fit you with a light-weight, stabilizing head frame in preparation for your treatment. The stability frame ensures your head remains in the same position throughout the procedure.
The Gamma Knife team prepares a personalized treatment plan for each patient. The team uses CT, MRI and/or angiography images that show the precise size, shape and location of the area that requires treatment. Using specially designed computer software and these images, the team prepares a plan the will be used to program the Gamma Knife equipment to automatically deliver the exact dose and number of beams of radiation needed to produce the very best possible results for that particular patient.The source of the radiation is called cobalt-60. Approximately 200 beams of this radiation are focused on the specific target from many different angles. Although there are a lot of beams of radiation, the dose of each beam is low enough so they don't damage the tissue through which they travel on their way to the target. It is only when they meet at the target that the combined dose becomes strong enough to destroy the target tissue.The smallest area the Gamma Knife can treat a tumor in the brain is 2mm to 4mm, but can the Gamma Knife treat a area in the brain smaller than this, and treat a area as small as 0.1mm or less.
you could make the holes the Gamma Knife beams go through, smaller to make the beams thinner in width, with the Gamma Knife beams made thinner, it would make where the gamma knife beams meet in the center, it would make a smaller meet area, so as to treat a smaller area in the brain.
I think making the beams thinner ,and using less than 192 beams say just 20 beams.
Using 20 thinner beams you could go eliminate smaller areas in the brain smaller than 2mm, could it be possible to eliminate a group of neurons in a area in the brain smaller than 0.1mm.
This way it can be possible to eliminate neurons on smaller scales, like on the micron scale.
If it cannot treat a area smaller than 2mm or 4mm, what needs to be done to the Gamma Knife to modify, upgrade, and push the Gamma Knife machine to its maximum potential limits, to be able to to treat a area in the brain less than 0.1mm.
Could it be possible to destroy a group of neurons in a area smaller than 0.1mm.
The Gamma Knife uses 192 holes, and the focused beams go through to treat tumors in the brain.
I want to see if its possible to eliminate groups of neurons in a area in the brain smaller than 0.1mm , which is 1000 neurons.The yet to be built INUMAC MRI machine can magnify a image in the human brain up to 0.1 mm, which is around 1000 neurons in the human brain.So it should be possible to eliminate groups of neurons at the 0.1mm scale if the Gamma knife can be modified/upgrade for a beam of radiation to be able to meet in the center of a area smaller than 0.1mmCan you answer these numbered question to help with my research.Question 1. So the beams of Gamma radiation come out of holes, how small can the holes be in order to make the gamma beams of radiation smaller.the smaller the holes the more thinner the gamma beams are going to be.with them being thinner, that means the meet area in the center where all the beams meet is going to be smaller.The question is how thin can the beams be made thinner, and with the beams being made thinner, from the smaller holes, how much will this make the meet area in the center smaller.Question 2. Is it possible to treat a tumor in the brain with just two beams of radiation, is this enough of a dose of radiation to effect the tumor.Because less beams means a smaller meet area in the center.The whole point of these questions is to see if the meet area in the center, where all the gamma beams come together, can be made smaller.The smaller the meet area, by making the beams of radiation thinner I think is the key to making the beams meet in a area smaller than 2mm, or 0.1mm which is my goal, this is what I want to achive.Where all the beams meet to I want to see if the Gamma knife can eliminate a group of 100, to 500 neurons, or smaller.
>If this cannot be done what has to be done to the Gamma Knife in terms of upgrading,modifying, and pushing the Gamma Knife to its full potential limits to be able to eliminate neurons on this 100 neurons small scale.

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#1

Re: updated Gamma Knife Question, thought of something new,

06/17/2014 8:03 PM

Doesn't it stand to reason that less holes and less beams means reduced exposure? So the direction, if any, that you should be taking, is more beams with smaller aperatures, to maintain the necessary exposure dose required for results....but then you begin to see that there is a limited space available with current methods, especially when we're talking 1000+ beams....The beam size would have to be smaller than the desired 0.1mm....and for each beam you need a piece of cobalt....If you can get 4 mm area with 192 beams, how many do you need for 0.1 mm.....I get 40*192=7680....

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#2
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Re: updated Gamma Knife Question, thought of something new,

06/17/2014 8:24 PM

However many beams you need for the amount of neurons that need to be eliminated in that area.

I am thinking, more beams makes a bigger meet area in the center, even if they are thin beams of Gamma radiation they will still make a big meet area in the center, if you use a lot.

I am not sure of how much dose is needed to eliminate neurons, or a tumor.

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#3
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Re: updated Gamma Knife Question, thought of something new,

06/17/2014 9:30 PM

...."dose rate varied from 1.21 Gy/minute to 3.74 Gy/minute (median 2.06 Gy/minute). Irradiation time varied from 26.73 to 95.11 minutes. The authors divided patients into a low-dose-rate (LDR) group, in which the dose rate varied from 1.21 to 2.05 Gy/minute, and a high-dose-rate (HDR) group, in which the dose rate varied from 2.06 to 3.74 Gy/minute. "...

http://www.ncbi.nlm.nih.gov/pubmed/21121798

definition gy...

"The gray (symbol: Gy) is a derived unit of ionizing radiation dose in the International System of Units (SI). It is a measure of the absorbed dose and is defined as the absorption of one joule of radiation energy by one kilogram of matter.[1]"

http://en.wikipedia.org/wiki/Gray_(unit)

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#6
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Re: updated Gamma Knife Question, thought of something new,

06/18/2014 12:30 PM

GA, Solar. This is precisely the crux that Nicholas does not understand. He has no understanding of either the Physics or the Chemistry of how ionizing radiation effects living tissue.

I doubt he understands the Physics of how Cobalt-60 produces the 1.3 Mev gamma radiation itself. He clearly has no understanding how one collimates light at these energies.

This is a complete non-starter pipe dream.

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#7
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Re: updated Gamma Knife Question, thought of something new,

06/18/2014 12:46 PM

For anyone interested, there is some very preliminary work being done on gamma ray optics.

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Re: updated Gamma Knife Question, thought of something new,

06/18/2014 3:00 PM

This would seem to be true, but everyone has to start someplace, and motivation is key....A highly motivated student is something to be nurtured...

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#9
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Re: updated Gamma Knife Question, thought of something new,

06/18/2014 3:25 PM

The more beams you have, the less radiation you get where you don't want it. However, there is a practical limit on number of beams due to cost and space restraints.

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#4

Re: Updated Gamma Knife Question, Thought of Something New.

06/17/2014 11:07 PM

I wouldn't entrust you with so much as a butter knife.

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#5

Re: Updated Gamma Knife Question, Thought of Something New.

06/18/2014 2:55 AM

Duplicate thread alert.

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#10

Re: Updated Gamma Knife Question, Thought of Something New.

06/19/2014 11:21 AM

The answer is still no. See previous thread.

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#11

Re: Updated Gamma Knife Question, Thought of Something New.

06/19/2014 1:22 PM

If you can achieve the resolution to image it, you should be able to achieve the resolution to "cut" it. Keep in mind that that, if achievable, this will still be a difficult problem. (That's one reason it's so interesting.)

CT and MRI already expose the patient to radiation, so your gamma knife will only be adding to that dose. Remember, radiation damage is cumulative. There is an upper lifetime limit. CT and MRI image from all directions in order to minimize dosage, among other reasons. Is your gamma knife going to re-expose those exact same areas?

Also, keep in mind that CT and MRI only work because of sophisticated computer programming and controls. Like CT and MRI, your knife is not going to be firing all of its beams at the same time. Emitters will be positioned, they will be energized then de-energize, then the re-positioned, energized, de-energized, and repeat until desired dose is delivered.

The patient will have to be restrained for a long time. Because of the extremely small volume you want to treat, I imagine you will have to fix the target site so that it cannot move in relation to the imager's reference points, then administer the gamma knife without moving the patient at all. Post-operative imaging will be required to determine effectivity. That person aint going anywhere for a while.

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#13
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Re: Updated Gamma Knife Question, Thought of Something New.

06/20/2014 12:37 PM

But the CT, MRI and Gamma Knife are all different types of radiation.

CT is created from X-ray radiation,

http://en.wikipedia.org/wiki/X-ray_computed_tomography

while the MRI subjects the patient to a very strong magnetic field to align the water molecules and then subjected to impulse RF radiation to excite those molecules, that then causes changes in the magnetic flux that is received to image the protons of the water. There is no ionizing radiation in an MRI,

http://en.wikipedia.org/wiki/Physics_of_magnetic_resonance_imaging

and the Gamma Knife as suggested by the name uses ionizing radiation in the form of gamma rays from the decay of radioactive cobalt to achieve its effects.

http://en.wikipedia.org/wiki/Gamma_Knife#Gamma_Knife

but I would imagine the OP already looked at the Wiki page on Gamma Knife. Right?

By the way, the Wiki on Gamma Knife is very 'optimistic'. It certainly has clinical uses, but even back in 2000, my investigation of the research into acoustic neuromas (I had good motivation to learn) showed that the outcomes for treatment of acoustic neuroma using Gamma Knife were not very good. Many side effects and collateral damage to nearby tissues causing facial palsy and other issues. The outcome of Gamma Knife was similar to micro-surgical removal in terms of patient satisfaction.

In Feb 2001, I had fractionated stereotactic radiosurgery at Johns Hopkins for my acoustic neuroma and I have been very happy with the outcome. My hearing in the left ear was toast (an annoyance to be sure), but I never had any problems with my facial nerves which can present significant social impacts as well as problems with the functioning of the eyelids and other issues.

This is my tumor 7 years after treatment. (Circled in the image)

No change in size and the image with contrast agent gadolinium on the right shows darkening of the tumor tissues indicating necrosis of the tumor.

Other than total hearing loss in the left ear (noisy parties or restaurants are no fun) I lead a normal life. No problems with vertigo or balance. I ride motorcycles on the street and trail, ski, water ski, and all those kinds of things.

Getting outpatient treatments (five visits being zapped) at the oncology center at Johns Hopkins made me realize how lucky I was to have such a minor problem. To this day, I still tear up when I think about the bald children on gurneys I saw there.

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#12

Re: Updated Gamma Knife Question, Thought of Something New.

06/19/2014 6:04 PM

A couple of questions to your long question:

--What causes the limit on the size treated? Is it the beam size or the focus ability of the equipment. Maybe passing thru tissue makes the beam waver?

--What about beam scatter as it impacts other atoms in its path? I'm guessing (I'm no doctor!) that the beam will spread a bit no matter how well collimated. There would also be attenuation of the beam strength.

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