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Predicting the Effects of Changes on Living Systems

Posted November 30, 2012 10:11 AM

From Phys.org - latest science and technology news stories:

Can scientists predict what happens when they introduce a change into a living system for example, if they change the structure of a gene or administer a drug? Just as changing one letter can completely change the meaning of a word, the change of a single letter of the genetic code (referred to as a single nucleotide polymorphism, or SNP) can subtly affect the meaning of a gene's instructions or alter them completely, making the effect of any change extremely hard to predict. Such changes are thought to be responsible for much of the variation between members of a single species for example, in susceptibility to different diseases. The ability to successfully predict the effect of such changes would accelerate drug discovery and provide a deeper understanding of the processes of life.

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Join Date: Aug 2009
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Re: Predicting the Effects of Changes on Living Systems

12/03/2012 12:58 PM

I don't know if I would be quite as sure as the poster who commented at the bottom of the article, but if I had to bet, I'd probably lean toward the same kind of ending that we've come to with Dark Matter and Dark Energy. Just when we think we are about to close the circle on how everything works, a big wrench gets thrown into the works.

Considering how little we, truly, understand about living organisms and "life," I suspect we'll miss the mark on closing that circle, too, because, chemistry rests on the principles of physics. Biochemistry is considered "macro" physics because it doesn't seem to operate at the nuclear level. (The controversial ideas of Louis Kervran, for instance, summarized in the book, "Biological Transmutations," ultimately, rests on LNER.) But now we have, what appears to be, a huge gap in understanding in our physics model. It might just impact our understanding of biological processes, too. I would suspect an incomplete model to propagate that incompleteness to any science that rests on it; in this instance, chemistry and biochemistry. Just how and where that "incompleteness" manifests is unpredictable with our current understanding. Similar to sports, predictions abound, but as they say, "That's why we play the games." So it is with science.

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