Problem with PW Loop Water

I would carry out an approved sanitisation procedure before doing anything else.

What are the guidelines according to WHO GMP or EU ?

What are the facility's standard operating procedures for this installation? Are there any? What is the end use of the water?

GMP? Another acronym that no body is familiar with......

I'm assuming right from the get-go that this water is supplied for human consumption....

The first thing you have to do is disinfect the water line if you are supplying water for human consumption. This will help immensely in prevent water-borne diseases sickening the population that you are serving. In the mean time order a "BOIL WATER ALERT" to all end users until you have disinfected the distribution system and have verified negative "BAC-T" results from a certified testing laboratory that you have acquired adequate disinfection of the system.

Check out the publications section in American Water Works Association website for applicable standards related to disinfection of water supply pipelines:

www.awwa.org

Secondly, to prevent this from happening again, provide enough disinfected water storage for no less than 2 days of the Average Daily Demand (2 x ADD). Make sure that any new storage tank is thoroughly leak tested and disinfected pursuant to AWWA Standards prior to commissioning (placing tank or tanks into service).

Thirdly, make sure that your disinfection equipment is fully capable of delivering fully filtered and disinfected water at least at the Maximum Daily Demand (MDD) and that you have redundancy (meaning two parallel treatment trains) in the event that one train has to be taken out of service for what ever reason, especially for maintenance purposes.

What you do depends on what the end user needs or desires.

If for human consumption, some form of line sanitation might be required (although I have seen water companies put city water mains back in service without "sanitization" with no adverse effects after a main break).

If this is for a manufacturing operation or process requiring high purity water, there should be in-house documentation explaining degree of purity needed and proper start up procedures. Follow them, or contact the supplier of the equipment for there reccommendations.

And who or what is a "GMP"?

cGMP: Current Good Manufacturing Practices,

We are using this water for our manufacturing process, and user loop is so designed that no water can stagnant at any point and it always circulate through the loop.

We have vent filters in the reserve tank and other accessories as required a Purified water plant in Pharmaceuticals Industries.

What my concern is, if user loop is become empty then what should we do? As I realize we should sanitize the loop as per our SOP. Is their any particular guidelines according to FDA or cGMP.

Thanks all of you.