Multiple Sclerosis, Explain "Localized Mechanical Damage" In The Lesions?

My research degree was in physiology and my special topic of interest was the nerve cell. There is nothing you can tell me about nerve cells that I don't know already.

Ok, good, then you know about nociceptors.

(Just so you know, I don't work for any research facility, University research lab, am unfunded, and have never made a living doing any kind of research unless you call the $1.65 an hour I made as an organic chem lab assistant in college in the late 60's, early 70's. Whatever I figure out about Lyme Disease, and specifically the metabolism of Borrelia, goes to independent researchers in that field who will use it further the good work they are already doing. My job in grad school was to "go to the library and read everything ever written about *** and come back in two days and tell us where the gap in the knowledge base is so we don't waste our time doing something someone else already did". )

Now, let me pick your brain a bit... because Borrelia b. needs two things it can get from the nerve synapses and since they are only 1 micron in diameter and only grow in length but not circumference as they mature they can go about anywhere they want to and stick one end of themselves into places you wouldn't ordinarily think about.

Here's a good close up picture of one:

They can excrete about 44 different Outer Surface Proteins through those nodes on each end, 28 OSP's are distinct and specific, the rest are modifications, mostly dependent on the species of the mammalian host. Some are heat stimulated, most are environment stimulated.

For the last year in delving into the different capabilities of Borrelia I keep ending up back at Glutamate.

Borrelia need glutamate and they need acetylcholine.

[If you doubt any of these facts, tell me which one and I'll post links to the abstracts or the DNA maps for the genes related to them.]

There is a high degree of joint pain involved in Lyme disease and they also need hyaluronic acid from the synovial fluid. They steal it for themselves. It is the lubricant for your cartilage.

Lack of it stimulates the nociceptors which release glutamate. To bring the glutamate to the porin specific to it they use an outer surface protein or ligand to bind the glutamate molecule to their surface. They lose that outer surface protein after they have had their fill of whatever it was used to collect what they needed.

Glutamate is also used in the brain and plays a major role in long term memory, specifically in the transfer from short term memory. It is also used in glycolysis, glucneogenesis and the citric acid cycle, disposal of waste or excess nitrogen, long term potentiation in the hippocampus and neocortex, and in neo-natal development it helps in the regulation of growth cones and synaptogenesis during brain development.

All of these can be directly related to one or more of the 80 or so symptoms of Borrelia infections.

DO YOU SEE A PATTERN DEVELOPING HERE?

So, you may see just from this list alone that depletion of reserves of glutamate by large numbers of Borrelia in the body can affect many different systems and may be the reason for the recent increase in autism and diabetes in increasing younger children, onset of short memory loss in Alzheimer's, Chronic Fatigue Syndrone, joint pain, etc., etc., etc.

Oh, and relapse of Lyme is caused by two things, cystic or round body forms containing m-RNA and super-coiled DNA 'mini-chromosomes' of Borrelia released by dying spirochetes that can later develop into a spirochete and then divide again while still in the cysts and bio-film colony clusters such as Dr. Eva Sapi has grown and isolated in her lab and done a lot of testing.

She really deserves a Nobel for that but they don't give one out for Biology because Nobel's wife ran off with a biologist. :)

So my very important question to you is:

Is there another source for acetylcholine in the human body because Borrelia can't make it themselves.

Did you know that ego can impair the connections between nerve cells in the brain? Tell us what you know about NO (nitrous oxide) and how it works both to facilitate nerve cell connections and to attack Bb? (NO is a poison to Bb) The NO stuff comes after you got your degree so it is probably alien to you. Bb actually makes a toxin to reduce production of NO in the body. This means that the attack that lyme makes on nerve cells with its toxin is both detrimental to the body AND makes life easier for Borellia. http://www.townsendletter.com/FebMar2006/Lyme_chart8.pdf Anyway, your bouts of severe egomania are not helping anybody. Can you explain the improvement in nerve transmisssion that my wife got other than the irrational implausible just plain stupid "remission exactly timed to coincide with the operation" explanation? I mean surely, with a degree, you got thought some imagination too? (Shaky video in the before was due to me being ready to catch her if she fell) Side by side Video of about a month before the op and 6 months after is at https://www.youtube.com/watch?v=LcI9bTNGo1Q

My reply to yourself and to #102 is the same; your understanding of the science is less than half-baked. Indeed, it would be polite to call it quarter-baked. There is therefore no point in continuing the conversation. Your posturing is not going to influence how the rest of the scientific profession views the problem.

I am not posturing. My videos are hard evidence that angioplasty works for some people. (It is about 1/3) and specifically it is the 1/3 who have autonomic system problems. Dr Arata has homed in on those people and he gets about 90% of patients showing improvements. (He only treats those who are likely to benefit). And by the way, every week a new study comes out from the vascular surgeons showing that their results are reality based. You have this weird idea that all the scientists are on your side about this developing technology and techniques. Nothing could be further from the truth. The guys on your side are generally clueless about the vascular system. If the science you understand does not explain reality, (it doesn't) then you are the one with the problem. The neuros are generally at a complete loss to explain how 1/3 of patients get fantastic improvment after this procedure. They have mumbo jumbo theories about it being the ultra hyped up placebo effect and that is the best that they can come up with. Pathetic really. If you have nothing more to add, please add nothing.

Relapsing fever (caused by a borrelia species) is also a disease of relapses and remissions. Who knew!! There are a bunch of newly discovered borellia species right now which seem to cover a range of disorders that mimic everything from relapsing fever all the way to lyme. One in Brazil that cannot be cultured outside the human, for instance. Anyway, it is impossible that the good doctor (dr arata) is getting all those remissions by chance within a day after having the operation. People in my circles love to quote "co-relation is not causation" and chide me with it. They have a strange reversal of mental math going on in their heads. The operation occurs and the remission happens the next day, in 90% of cases at Synergy health. Sorry folks, that IS causation except on planet id-iot. It is a stronger co-relation than on most drug trials too.

Ok, I figured it out. Here is what happens...

Borrelia needs ATP to survive, who doesn't? They don't have an innate Krebs Cycle so they steal it anywhere they can, from the outside of red blood cells, the outer surface of smooth muscle cells, basically anywhere they come into contact with it.

They also can excrete an sticky Outer Surface Protein that they use to attach themselves to the surface of the smooth muscle cells of the circulatory system.

In the white matter of the brain they can accidentely trap themselves in the capillaries there by stealing the ATP from the pre-capillary sphinctor muscle at the arteriole end of the capilaries in the capillary beds.

If the pre-capillary sphinctor happens to be constricted when a spirochete is travelling through the circulatory system of the white matter, then that sphinctor will not be able to open back up. The pre-capillary sphinctor muscles in the white matter of the brain act like releasable zip ties, they have an actin 'ratchet' system so that when they are in their relaxed state they stay where they are. They have to be actively opened up which requires more ATP.

This can trap a lot of spirochetes in a lot of capillaries since there are millions of capillaries in the white matter of the brain.

When the balloon angioplasty your wife had done to her jugular vein it put enough back pressure to the capillaries of the white matter of her brain, forcing the pre-capillary sphinctors to ratchet open, flushing out all the clogged ones releasing the trapped spirochetes and other debris, thus allowing normal circulation throughout the entire white matter circulatory system.

After that it was simply a matter of her white blood cells cleaning up the mess.

Read about Hypothiocyanate and how white blood cells work 50-500 times more effectively to kill bacteria and clean up the toxins from the dying bacteria if Thiocyanate levels stored in the liver are normal.

Good luck sir!

First of all, thanks for the last reply. I only post where there is some interest and lately CR4 has been quiet. I may have mentioned it before, they have found receptors on veins that detect stretch (and thereby volume of blood) and send that signal through the autonomic nervous system to the brain. This is part of the info that the brain uses to distribute blood around the body. These nerves in people with MS and in people with Lyme do not seem to be working properly in the neck area. There has been tons of research about veins in brains lately. This is one of the better ones, they have found an entirely new way that the arteries dilate! It isn't nerves and the dilation message travels along the vessel wall. Perhaps some chemical signal because it is slow. (I imagine this to happen like a worm moving). "New results suggest that the continuous pathway of endothelial cells within the brain's arteries is essential for propagating signals that orchestrate local dilation and increases in blood flow in response to local neuronal activity." http://engineering.columbia.edu/columbia-engineers-provide-new-insight-how-brain-regulates-its-blood-flow is the link. There has also been some work on the problem veins and valves in the necks. In MS patients, they (the valves) are missing an entire layer of cells! (The 2 groups do not seem to have connected or joined the dots) http://phl.sagepub.com/content/early/2014/06/27/0268355514541980.abstract I also attended a Lyme meeting a couple of months ago in Victoria. We (officially) have 15 to 20 cases of Lyme in BC (pop about 4.2 million) per year. There were about 100 people in the room. (just from the Victoria area (pop about 300,000) (and this was certainly not all the Lyme people from here). 40 people in the room had Lyme confirmed by tests in USA! But they are not counted! I was pretty upset. I had never seen so many twitches, and frankly people behaving weird and spaced out , and dark glasses (light sensitivity) and crutches and wheelchairs in a room before. Such a shock that our medical system pretends that this does not even exist here. And these people are allowed to give blood donations! (A Lyme sufferer told me this). Are the medical profession barking mad? The only people who are allowed to treat Lyme with antibiotics for any length of time in BC Canada are the Nature-paths because the doctors get in trouble if they do! Insane. They can give stronger medicine for Acne than for Lyme! Here is a video I took of a poor lady with Lyme from just north of Victoria. She is in a really bad way and I had to help her to and from her seat. She has a bunch of co-infections too. https://www.youtube.com/watch?v=RuRxgAaW5s0

http://www.lymeneteurope.org/forum/viewtopic.php?f=10&t=4891

This worked for me twice.

I also meant to add that when Thiocyanate levels are low and the immune system overtaxed that the white blood cells cannot clean up the 'toxins' released when the spirochetes die a natural death from being trapped without nutrients or a source of energy.

Since they are expressing Outer Surface Proteins they use to attach themselves to the smooth muscle cells of the circulatory system, those sticky proteins will be washed out intact and most likely end up stuck to the inside of the jugular vein where T-cells and antibodies will recognize them as antigens and inadvertently destroy the inner layer of smooth muscles lining the vein.

Links available to research papers already published on all these manifestations of Chronic Lyme if you want them.