Artificial Antigen-Presenting Cells (aAPCs) Boost T-cell Mediated Immunity

From Medgadget:

Biomedical engineering professor Tarek Fahmy and graduate student Erin Steenblock from Yale are reporting in the upcoming issue of Molecular Therapy the development of biodegradable microparticles specially designed "for attaching both recognition ligands and co-stimulatory ligands to a biodegradable core encapsulating the cytokine interleukin-2 (IL-2)". The particles, constructed from polymer poly(lactide-co-glycolide) (PLGA), have been shown in the group's experiments to produce a 45-fold enhancement of T cell activation and expansion

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