Shell Around Effective Combatants to Alzheimer's

There are other countries in the world beyond America. Lyme disease is not found in many of those other countries but Alzheimers is. Whilst I accept that it is quite possible, even probable that the Borrellia Burgdorferi spirochete causes a dementia it is most certainly NOT the cause of correctly diagnosed Alzheimers. As it is still widely held that Alzheimers can only be diagnosed with a high degree of probability post mortem, it would seem to me that B. Burgdorferi has somewhat thrown a spanner in the assessments of past years. That is to say that past post mortems may have ruled out Syphilis, toxoplasmosis, CJD, trauma and a host of other causes of dementia but not known about and therefore not seen B.Burgdorferi, and so this theory may help explain and eliminate another non Alzheimers cause in some people but not all. His theories certainly don't explain Alzheimers in Lyme disease free countries.

Jim

Perhaps a general theory could be found for alzheimer's. Chemists, engineers, physicist, genestists, all have their own approach to theories. For example: ring structure, catalysts, periodic table, positive and negative elements, force equals ma, current equals e over r. Therories that physicists try out with linear accelators, ideas by genetists, etc. Perhaps one has to go backwards. What are the effects of alzeimer's, what actually happens? Then take baby steps backwards.

This is good:

In their study, the researchers found that a fragment of the molecule nitroglycerin-a second FDA-approved drug commonly used to treat episodes of chest pain or angina in people with coronary heart disease-could bind to another site that the Lipton group discovered on NMDA receptors. The new drug represents a novel synthesis connecting this fragment of nitroglycerin to memantine, thus representing two FDA-approved drugs connected together. Because memantine rather selectively binds to eNMDA receptors, it also functions to target nitroglycerin to the receptor. Therefore, by combining the two, Lipton's lab created a new, dual-function drug. The researchers developed 37 derivatives of the combined drug before they found one that worked,

See link above. (I am not sure what the number is, but I don't want to lose this comment.)

By shutting down hyperactive eNMDA receptors on diseased neurons, NitroMemantine restores synapses between those neurons. "We show in this paper that memantine's ability to protect synapses is limited," Lipton said, "but NitroMemantine brings the number of synapses all the way back to normal within a few months of treatment in mouse models of Alzheimer's disease. In fact, the new drug really starts to work within hours."

To date, therapies that attack amyloid plaques and neurofibrillary tangles have failed. "It's quite disappointing because I see really sick patients with dementia. However, I'm now optimistic that NitroMemantine will be effective as we advance to human trials, bringing new hope to bot

This is Lipton talking.

This is Heidi using Goggle: 0,000 results (0.24 seconds)

Search Results

Synapse - Wikipedia, the free encyclopediaen.wikipedia.org/wiki/Synapse‎In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another cell (neural or otherwise).‎Chemical synapse - ‎Electrical synapse - ‎Synapse (disambiguation)

Heidi again using Goggle:

Structure of a Neuron

By Kendra Cherry, About.com Guide

1 of 6 Previous Next Neurons Ad

Free Anatomy Worksheetswww.education.comPrintable Anatomy Worksheets. Help Kids Build Skills!

Neurons are the basic building blocks of the nervous system. These specialized cells are the information-processing units of the brain responsible for receiving and transmitting information. Each part of the neuron plays a role in the communication of information throughout the body. Follow the links below to learn more about the functions of each part of a neuron.

All part of the problem: Heidi on Goggle:
Alzheimer's Disease: Unraveling the Mystery | National Institute on ...www.nia.nih.gov › ... › Part 2: What Happens to the Brain in AD‎The brains of people with AD have an abundance of two abnormal structures-amyloid plaques and neurofibrillary tangles-that are made of misfolded proteins ...

Another addition from google:

Alzheimer�s disease
One of the main characteristics of Alzheimer�s disease is the accumulation of plaques of insoluble b-amyloid in the brain. It is still not certain whether these plaques are a cause or a consequence of the disease, but there is a lot of evidence for the former being the case. The b-amyloid plaques are formed by cleavage of amyloid-precursor protein (APP) by two different enzymatic activities, which release amyloid-b peptide fragments that are 40 or 42 amino acids long (Fig. 1). These then form fibrils, which aggregate into insoluble clumps of b-amyloid plaques that surround neurons and might cause damage.

Actually, I would call the plaques a symptom...the inability to turn short-term memories into long-term memories is another. Kinda a vicious circle composite of disrupted metabolic processes leads to both.

The hippocampus is where Reelin modulates the NMDA function which enhances LTP which changes short-term memories into long-term memories and also orientation. Lack of Reelin also causes an abnormal reeling gate when is it lacking in the hippocampus, a telltale symptom of Lyme disease.

The body also produces Reelin to counteract Aβ induced dampening of the NMDA receptor activity. NMDA requires co-activation by Glutamate + Glycine. Is not enough of either is present then memory is affected again as APP is required for Long Term Potentation [Zheng H, Koo EH 2006]. (Borrelia uses glutamate but cannot produce it.)

Neuronal Cell Bodies contain LESS APP relative to their proximity to Amyloid Plaques. APP could be getting used up in excess by other processes in Alzheimer's.

APP possesses ferroxidase activity facilitating iron export BUT this activity is blocked by ZINC trapped by accumulated Aβ in Alzheimer's. (Possibly used up by apoptic red blood cells spilled out of ruptured capillaires.) Zinc also blocks NMDA current activity.

Borrelia uses Zinc instead of iron in it's Peptide Deformylase catalyst and is essential for all of it's protein synthesis. It possesses it in quantity.

Reelin also increases NR2B subunit mobility leading to NMDA receptor maturation as part of the synaptic formation and repair process.

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005505

Reelin is produced continuously but if it can't reach the affected area to counteract Aβ because of blocked or damaged capillaries things get out of control.

Zinc is famously abundant in amyloid plaques as well as Borellia...

This is amazing work!
http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000090#ppat.1000090.s003

In this pic you can easily see that the Borrelia spirochete is attached to the capillary sphincter!

http://www.plospathogens.org/article/fetchObject.action?uri=info:doi/10.1371/journal.ppat.1000090.g004&representation=PNG_I

Why not try to think like a civil engineer and treat fibers in the brain like underground cable? They both have their problems. It seems like the civil engineer people have done pretty well. BioMech & BiioMed, chemists, etc. should be able to catch up.

Going backwards perhaps - not really:

What are proteins made of?

The ingredients of a protein are amino acids. To build a protein we need to build a long chain of amino acids. There are 20 different types of amino acids, so there are lots of different protein chains we can build. Biologists give amino acids a code letter, as for DNA. This is much easier than writing out the whole name each time. For example, M is methionine, L is leucine, F is phenylalanine (because P is proline).

This is not quite the "GREAT ANSWER." For one thing, I'm guessing that many of the suffers of true Alzheimer's disease have never been exposed to Lyme disease. Furthermore, a woman scientist in England has found Herpes Simplex 1 DNA in the brain cells of Alzheimer's patients.

OK, this may point to an environmental cause, but I think we're still a way away from a slam-dunk.

I need to think about your comment. Sounds good.

Here is one:Skip Navigation

'Hereditary disposition' doesn't necessarily mean a disease is completely caused by a breakdown of the normal in vivo processes.

Say, if a pathogen (Borrelia) is stealing the L-glutamate from the nerves in the white matter in order to turn it into to D-glutamate and using it for it's own cell wall repair, then a patient's ability to produce enough of it for the patient's own processes would be the restriction to good health.

http://www.uniprot.org/uniprot/O51127

Some people's ability to produce enough of a necessary compound to feed the pathogen and themselves is the fine line between a symbiotic infection and a pathogenic infection.

Good article. I saw prof. Ralph Martins was a contributor to this article while he was working at UWA. It reinforces that spirocetes of different flavours can cause dementia but not Alzheimers. The research has started to accelerate towards the finish line and it looks to me that an answer is imminent. Once the causative factors are known the long grind to find a cure begins unless there is a 'happy accident' along the way.

To go off on different tangent; I admire all the people have experimented towards a set goal and found something completely different in what i would have seen as an embarrassing failure. Such as the dye colour mauve as the end result of a failed search for a cure for malaria. Yay! I can again insert emoticons. ( Win8 Outlook ) maybe I can insert pictures as well. Back to "The Elegance of Nature"

Jim

Professor Ralph Martins from Edith Cowan university announced just days ago that he can now detect the likelihood of an individual getting Alzheimers in the next 20 yrs. He reports that he can now "see" the amaloyd deposits building up in the brain in the early stages. He can most certainly see and diagnose Alzheimers in the brain of people who have the disease. This is as a result of many years of research and undoubtedly will be scrutinized by the rest of the medical fraternity throughout the world in the near future.

Jim

Why not a hand book on alzeimers. Chemists and Chemical Engineers have one. Amaloyds (spelling?), sugars, etc. are involved. Molecular structures, flow of electrons, degrees of twisting proteins, degrees of severity, methods stopping the twisting of proteins. Organic chemistry can be quite involved. Just think of all the organic compounds that can come from gasoline: Ketones, aldehydes (spelling, alcohols, benzene, staight chains of of carbon (methane, propane, etc.) Why not shift empahasis to alzeimers?

That looks like my old copy of that book! About the right age too, lol.

Where Alzheimer's plaque come from:

At the junction of each capillary in the white matter of the brain where it connects to arterioles, there is a tiny single smooth muscle that closes off the capillary for a second or so in a random order so as to allow oxygen and nutrients to disperse and CO2 and other waste matter to be absorbed into the blood stream and taken out of the brain tissue. The tiny smooth muscle is called the pre-capillary sphincter muscle and it is exposed to the inside of the capillary.

The spirochete's have an Outer Surface Protein that allows them to attach themselves to this smooth muscle and steal it's ATP for themselves.

This blocks the smooth muscle from opening back up the capillary to blood flow. The red blood cells die and get trapped in the capillary (along with everything else that was in it).

You have millions of capillaries there so it won't kill you but robs that tiny part of your brain of some of it's oxygen.

Open this article: [ http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000090 ] and scroll down to the paragraph titled: 'Three-dimensional visualization of spirochetes interacting with the host microvasculature' and look at Figure A. You will see a Borrelia spirochete attached to the Precapillary Sphincter Muscle.

The capillaries can repair themselves by creating a film over the trapped dead blood cells and splitting open along that side, dumping out the contents, and then closing up the split. The dumped material is where the plaque comes from in Alzheimer's, which Lyme induced 'brain fog' mimics.

Because the dumped dead red blood cells contain Iron, the body releases Reelin [ http://en.wikipedia.org/wiki/Reelin ] from the hypocampus to clear out the toxic iron molecules.

Reelin has many functions in the body but one of them is that it helps to control your ability to walk in a straight line. That's where the MS Shuffle comes from.

Thanks for your comment. I need to study this some more.

But, without any available cures, would you want to know you were going to develop Alzheimer's?

May I be permitted to suggest some research on some harmless treatments for Alzheimer's starting with YouTube just type in Alzheimer's and Coconut oil you will get several videos of remarkable reversals of this disease. Also go to the MMS site and read some testimonials. http://g2cforum.org/index.php/list/alzheimers-and-dementia/8454-mms-success-with-alzheimer-s-and-other-conditions. The MMS product is a safe chelate of toxins but you may use other products although I am not familar with their effectivness. Final product is from company in RedDeer Alberta Canada called TruHope and has worked miracles in many cases with brain disorders. It is a nutritional suppliment that targets the brain. All these have very solid track record for success but not any of them are 100% but then again what does grant 100%?

Coconut oil is good for everything, and solves all problems according to many threads on this forum.

I agree is a wonderful oil that appears to have no negative consequences if used according to protocols. I use it for all high temperature cooking and olive oil for all low temperature and cold applications. Keytones, lauric acid ( great for the skin) Anti fungal, anti bacterial are also good and proven benefits. Be sure to use organic, extra virgin and cold pressed.

Coconut oil??Wonderful stuff! I use lots of it in the sulfated and sulfonated, amidized, betainized, oxidized and ethoxylated forms as well!

What I recently learned is that there in fact be a connection between Alzheimer's disease and diabetes (of the type that appears to be organ specific insulin resistance), newly referred to as Type III Diabetes. I have a friend in the pharmaceutical business who is very interested in transport mechanisms of cells, and may have the answer to insulin (and sugar) transport. If this is indeed the cause, and if this works, a diagnosis and a cure to the disease may already be in the pipeline.

It's interesting that you mention sugar as Prof Martins said that he believed the cause of the amaloyd buildup is sugar and fat. As these are the food ingredients I like most I certainly hope he is proved wrong on this aspect. He also said that diabetes increases the likelihood of developing Alzheimers.

Jim

As the brain relies on sugar (glucose) for energy, and has to have certains key lipids to maintain the structure, etc., it would appear that a diet high in the wrong forms of sugar (such as high fructose corn syrup, or certain artificial sweeteners), and the wrong fats (such as all saturated fats all the time) could indeed lead to problems in the brain (as well as elsewhere).

I try really hard to limit simple sugar intake to fruits and chocolate of the darker variety. There again, I am not the paragon of good health.

Sugar is a factor for sure as are heavy metals and hormone mimicking elements used in various sprays. The brain does use sugar but it is not necessary as the brain will convert body fat into ketone's for same purpose as sugar. Diabetics have higher incidence of Alzheimer's probably due to the sugar insulin issues. Bottom line is this, as humans we get far too much sugar in our diet. As mentioned the brain is the only organ that uses any sugar and it has alternatives to sugar. Also cancer must have glucose and as a group we are feeding this disease due to ignorance and dependency. Sugar is in all high glycemic foods and this takes due diligence to eliminate the damage.

While I agree that HFCS is probably going to be proved as a real villain for the human body (liver, pancreas, etc...), when it comes to the brain, I don't think it has a "direct" impact. The only sugar that crosses the blood-brain barrier is glucose. Whatever form of sugary substance you ingest, it don't hit the brain (again, "directly") until it's ripped into glucose.

So-called "bad" sugars have to be processed by the liver to fatty lipids for storage, and then converted back. I am not too sure what the result of transformation of fructose to fats results in as far as the make up of the exact fatty acids produced, but I expect these are not the ideal ones needed.

Interestingly enough, if you check the molecular structure of amyloid plague, it looks surprisingly close to formaldehyde... However, formaldehyde doesn't stay in the body very long before the liver converts it to formic acid, which REALLY messes you up!!!

FORMALDEHYDE!!! Now you have hit the nail on the head.. Artificial sweetners of the aspertaine family , splenda, sucralose, aspertaine, and all the other manufactured ones are derived from sugar but use or convert to methyl hydrate then into formaldehyde. There are countless studies on the devastation caused by formaldehyde in the body. This relates almost directly by the numbers to the increase use of these products and the epidemic of Alzheimer's and other neurological diseases.

Listening to a weekly radio program 'Dead doctors don't lie' a Dr. Wallach who is a proponent of vitamin therapy suggests that lack of cholesteral and the overprescription of cholesteral reducing statin drugs contributes to alzheimers.

Funny thing about health care, doctors never seem to agree on what is best practice. First they tell you chlolesterol (in your arteries) of the LDL type will kill you, then they want to tell you lack of it will also kill you. Obviously, with an American diet, I am in no danger of a chlolesterol deficiency. My grandmother made her own butter (from milk she milked from milk cows). Ate butter her whole life, lived to a ripe old 84 years of age, but did have heart disease the last few years, as I understand. Mother lived to 89, but with several heart episodes. Neither of them was ever on statin drugs, as these were simply not around.

Rather than just making it to 90 years old (and being decrepit and in a "rest" home), I would rather make it to 80 or so and be as spry as I am at 60. We shall see what is best.

You won't need vitamin therapy if you eat right and don't smoke or drink and get 20 minutes of real exercise every other day that makes you sweat.

Does anyone remember the food pyramid?

What is disturbing is that the USA has one of the most secure and easily available food supplies in the entire world and the worst health because we eat junk food and fast food instead of cooking good fresh meals 3 times a day and sit in front of a computer or the TV instead of playing outside or getting the 20 minutes of exercise it takes to stay healthy.

Not everyone is like that but too many are. Type I diabetes is 150% more common now than in 1985 because of this.

When I was studying biochemistry at IU in the early 1970's the pre-med guys in my classes weren't smart enough to be scientists, that's why they let them into med school. Half of them wanted to be Doctors just for the paycheck and early retirement.

Does your doctor tell you to eat healthy, get plenty of fresh air and exercise and 8 hours of sleep, don't smoke and drink only in moderation?

If not get a second opinion.

Added information: Autism used to be one in 5000 now one in 50, Heart attack and other coronary issues were almost unheard of when I was child in the 50's now a major killer. You mentioned diabetes, another disaster as well as autoimmune conditions such as bowel disease, allergies, arthritis and rheumatism. Alzheimer's can be helped and reversed with coconut oil and or the ketosis diet. Good reading is the work done by Kerri Rivera with autism and the protocol to recover these children. Great work by a mother of an autistic child with 122 recoveries but more important the improvement in over 8000 victims of autism.

Yes, this would probably do it...

Recent work on how Borrelia use partially exposed outer surface proteins to bind metal ions to itself...how it steals Zinc and Manganese for itself through use of outer surface proteins that bind to other cells porins.

http://jb.asm.org/content/195/15/3320.long

People may get pissed at me because of this, but it's looking like prions are single, complex proteins and not a multi-protein structure.

Not 'prion', i'm talking about Porins, cell wall gateways for external thingies to get into cells when needed.

http://en.wikipedia.org/wiki/Porin_%28protein%29

Oh! Well that's different. Never mind.

Actually, they are related, both being protein based and dependent on neucleotide signaling to get things moving.

For example...

http://onlinelibrary.wiley.com/doi/10.1002/iub.1212/abstract

I just happened across this post, which Alzheimer's first grab my interest, and then reading about lymes, I had the symptoms last year, but in my case lymes test showed negative, but I did have a bacterial infection (probably got infected working on cooling towers)

But what was mentioned, this could also be related to Creutzfeldt-Jakob disease (Mad Cow Disease), which causes native cellular prion protein to deform into the infectious state, that would have a cascading effect on further degradation on other prion proteins.

It's quite interesting on whether there is a connection………..

To make a chemical compound flip it's 3D conformation to an alternative one, there has to be a catalyst. The catalyst (by definition) doesn't get used up in the process so it doesn't go away until it either gets degraded or eaten up by macrophages or isolated in the system.

Look for the catalyst. A simple gas chromatograph comparison of normal and infected serum might show the oddball catalytic compound.

^{Turns out that the human body's natural brain plaque dissolving compound is a Serine Protease:}

https://doi.org/10.1038/nchembio.1931

And glyphosate is a general Serine Protease Inhibitor , pages 27-28 here::

http://www.organic-systems.org/journal/92/JOS_Volume-9_Number-2_Nov_2014-Swanson-et-al.pdf

Excess Alzheimer's plaque builds up when this process:

https://news.feinberg.northwestern.edu/2010/05/26/capillaries/

Gets ahead of this process:

https://www.npr.org/sections/health-shots/2013/10/18/236211811/brains-sweep-themselves-clean-of-toxins-during-sleep

G'day 129CBRider, i couldn't open the link as my computer says it is a security risk. Does the article say the use of Glyphosate is a possible cause of dementia?

I am aware that the mouth is full of spirochete bacteria and they don't necessarily cause dementia but some may. Certainly the syphilis spirochete can and does cause a dementia and can be passed from person to person. If other mouth spirochetes can cause a dementia then kissing can be bad for our health!

I, like many on this forum, use Glyphosate regularly. I am now worried.

Glyphosate is a general Serine Protease inhibitor.

Our compound we make to remove plaque from the brain after capillaries dump it to clear clogs is a Serine Protease

https://europepmc.org/article/med/3297997

https://www.npr.org/sections/health-shots/2013/10/18/236211811/brains-sweep-themselves-clean-of-toxins-during-sleep

https://news.feinberg.northwestern.edu/2010/05/26/capillaries/

https://pubmed.ncbi.nlm.nih.gov/26436840/

pages 27-28:

http://www.organic-systems.org/journal/92/JOS_Volume-9_Number-2_Nov_2014-Swanson-et-al.pdf

https://pubmed.ncbi.nlm.nih.gov/2760500/

Thanks for this info.

Jim