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Science and Sentiment - U.S. Army Ends Controversial Chemical Program

Posted October 14, 2011 11:49 AM by Steve Melito

Yesterday, the Army Medical Research Institute of Chemical Defense (USAMRICD) at Aberdeen Proving Ground announced that the Maryland facility will "phase out" animal testing that simulates a nerve gas attack. During these tests, vervet monkeys are injected with high doses of nerve-blocking drug called physostigmine that is also used to treat the nerve disease myasthenia gravia in humans (although at much lower doses). The Army medical personnel who treat their primate patients then learn how to respond to chemical weapons attacks on troops.

As the Washington Post reported, the Army's decision came "after sustained pressure from animal rights groups and a member of Congress," Rep. Roscoe G. Bartlett, who once worked at the Navy's School of Aviation Medicine. The Post also described how high doses of physostigmine affect vervet monkeys, and even featured a screen capture and video from past tests. (Viewer discretion is advised.) Although the newspaper succeeded in appealing to the sentiments of animal lovers, the Post failed to substantiate its claim that "trained actors, computer programs and high-tech, mannequinlike patient simulators" can adequately replace live animal testing.

So how well will these substitute methods work? Is information about these technologies so secret that Post reporter Brian Vastag couldn't describe them in some detail? Or is it simply easier to tug at readers' heart strings than to explain how computational fluid dynamics (CFD) can be applied to the dispersion of chemical and biological agents? By interviewing experts such as Eric Toner of the Center for Biosecurity at the University of Pittsburgh Medical Center, the Post did describe the scientific shortcomings of animal testing. But it failed to make a convincing case that "there are lots of technologies they can use instead," as Rep. Bartlett claims.

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#1

Re: Science and Sentiment - U.S. Army Ends Controversial Chemical Program

10/14/2011 1:29 PM

A win for the loony left!

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#2

Re: Science and Sentiment - U.S. Army Ends Controversial Chemical Program

10/15/2011 12:20 AM

"An independent expert agreed that patient simulators, which can be programmed to show symptoms of a nerve gas attack, would provide better training." I guess my question would be, What base line are these patient simulators going to based on? With Saddam Hussein out of the picture and I don't think that there's too many WWI Vets left to explain what effects of Nerve Gas were like.

Wonder if Rep. Roscoe G. Bartlett or Woody Harrelson would step up to the plate and allow testing on themselves so that these " Patient Simulators" would project accurately, the effects and symptoms of chemical and biological agents? Just wondering

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#3

Re: Science and Sentiment - U.S. Army Ends Controversial Chemical Program

10/15/2011 6:40 PM

The treatment of nerve gas poisoning is pretty straightforward, according to the wiki. Atropine/biperiden is the first level antidote, usually by autoinjector. The second antidote is pralidoxime chloride, which takes a bit longer to act.

The poisoned person will be convulsing (until antidote is administered) and a mess due to the secretion of excess saliva, tears, mucus etcetera, so some respiratory and maybe positional support is evidently what is needed while the patient returns to normal.

I am not convinced that the caregivers are better trained by working on poisoned animals. Like the article said: "The physiology is not accurate," said John J. Pippin, a physician with PCRM. "Many of the first signs in humans - sweating, dilation of pupils - can't be assessed. Also, participants in the course don't actually do anything except hold a bag to help the monkey breathe."

I watched the video, I don't think a little monkey lying on a cot is really relevant to the field situation you can imagine, where big convulsing men have to be injected with antidote ASAP and helped to breathe. And maybe stripped and or hosed off if it's V gas. If I was waiting for "bronchial secretions to clear" I think I'd be sitting leaned forward with my arms on my knees, if possible, not lying in a pool of saliva on a cot... but a monkey doesn't have the same physiology, there's no learning here about what is optimal for the human patient's recovery... and no hands on practice in handling a heavy man who's convulsing and choking.

They've only been doing the monkey routine since 2005, not like it was the gold standard in training or something. I think they'd be way better off with a patient simulator.

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#4

Re: Science and Sentiment - U.S. Army Ends Controversial Chemical Program

10/16/2011 7:37 AM

Nerve agent scenarios have been played out with deployment exercises since the 1950's, the ARMY stopped a program that was already obsolete. The use of ballistic and blast injury on goats and dogs are still being done in numerous facilities in the DOD....no important projects have been sacrificed...especially the more sophisticated biologic agent programs.

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