Biomedical Engineering Blog

Biomedical Engineering

The Biomedical Engineering blog is the place for conversation and discussion about topics related to engineering principles of the medical field. Here, you'll find everything from discussions about emerging medical technologies to advances in medical research. The blog's owner, Chelsey H, is a graduate of Rensselaer Polytechnic Institute (RPI) with a degree in Biomedical Engineering.

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Regenerating Teeth

Posted October 14, 2014 12:00 AM by Chelsey H

No more veneers? Maybe. This blog post is timely considering my sister fell last week while running and chipped her front tooth in half. I wish I had known to suggest that she seek laser treatment to encourage regrowth of her broken tooth (although I doubt she would have wanted to wait so long).

Research shows that lasers can help regenerate heart, skin, and nerve tissues. Low levels of laser light can trigger chemical reactions that promote wound healing, reduce inflammation, and treat pain. New research in Science Translational Medicine shows that lasers can help regrow parts of broken teeth and potentially make fillings, crowns, and other dental necessities obsolete.

A false-color image from a scanning electron microscope depicting the scaffold seeded with cells used to assess laser treatment effects.

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For the study, scientists at Harvard University looked at dentin, the tissue that makes up the bulk of human teeth. Dentin is harder than bone but softer than the enamel that coats teeth. The goal of the research was to encourage dental stem cells to regenerate as dentin. But instead of implanting modified dental stem cells or injecting chemicals to control dental stems cells in patients, the researchers wanted to activate proteins, known as growth factors, that are already in the body and use them to manipulate dental stem cells through the use of lasers.

Instead of using synthetic materials, such as ceramics, to repair a tooth, a laser would be shone on the tooth and soft pulp underneath (from damage). The laser generates chemicals known as reactive oxygen species which activate a growth factor called transforming growth factor beta-1 (TGF-b1) in the body. This molecule stimulates dental stem cells to repair teeth as well as many other tissues.

Experiments have been done on rats and adult dental stem cells extracted from human teeth. Results show that low levels of laser light activated TGF-b1 and led to the generation of dentin-forming cells. The next step is taking their work to human clinical trials.

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#1

Re: Regenerating Teeth

10/14/2014 12:22 PM

do not know how this really influences regeneration.

After having my (4) front teeth knocked out back in junior high. and having them capped for over 35 years with little problems but the past 5 years (over 40 years total) I had to have implants put in at a cost of about $10,000.00.

It would be interesting to know and the quality of the regenerations.

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#2
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Re: Regenerating Teeth

10/15/2014 7:01 AM

My one of tooth in top jaw got cavities. Doctor asked me to get it capped with ceramic cover. It cost me only only $50.00, here in India.It is o.k since past 5 years. Medical treatment in India is very cheap and of good quality. Many people with heart bypass surgery come to India as it is even worth paying air ticket and stay. Average cost is $12,000/- I mean hospital expense only in international class hospital.

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Re: Regenerating Teeth

10/15/2014 8:00 AM

not to mention hip replacement.

this is going a little off topic.

There discussion about 10-15 years ago, where the same drug from the same drug company was cheaper in Canada without this drug being subsidied by Canada than in the United State,

The justification of this was that it costs money to develop these drug, That I can understand, but the explanation went on to say that the prices were structured on the ability on the people on which they could pay.

The other thing is, in the last 15 years, in our city of over 100,000 people, the amount of new major hospitals that were constructed triple then were before (Before we had three), Not including the minor urgent care facilities.

now 20 years ago, our city was at about 70,000 people, so I can see the growth.

10 years ago, I had a undiagnosed health issues they were trying to track down so to speak, where it turn out to be a PFO. I was one of the first patients that was put in a new (3) story addition of top of one of the established hospital, and on the cardio floor, I was the only person there. To say the least, I had a army of nurses that could do enough for me. (Just due to the lack of patients. This was 10 years ago, and I was still receiving bills from this hospital up until 2 years ago. of course it was only $225.00. But this was a little ridicules. (This bill actually was brought to my attention through a collection agency.. whichwas at the least very embasserssing. I contacted the hospital immediate and squared it away, as well as making sure my personal information was updated.

These hospitals now are structured as profit houses. But I like to add that the established hospital that just had an addition was a non-profit, and was l leader in the nation for cardio care. unfortunately, that had originally miss diagnosed me. miss as in missed, they did not catch it initially that lead to problems later on.

I didn't realize seriousness of the problem, until I got a second opinion from this hospital.

The first hospital, realized they missed it, and was down playing the seriousness because they were afraid of lawsuit. One thing I realized, is that mistakes happen.

The healthcare systems is expensive here, and with the healthcare reforms that put in in place, I feel is taking away was good about what we had, and will soon give us mediocre healthcare.

But that's my opinion.

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#4
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Re: Regenerating Teeth

10/16/2014 6:02 AM

Hi Phoenix, I am sorry to hear that you had PFO, it is very rare problem. My friend's son had PFO from his childhood but lived up to age of 35 years, finally died about 3 years back, as doctors here said there is no treatment. I hope you are now out of this problem. Hospitals everywhere in world have been commercialised. But fortunately for us they are still cheaper here. People are able to manage it with medical insurance.

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#5
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Re: Regenerating Teeth

10/16/2014 7:48 AM

Thanks, Suresh.

As I understand it, everyone is born with these hole in the heart, all but about 20% this hole would close.

And of the 20% a very small fraction would have issues. Stress is the culprit in most cases.

After a severe..... episode. It took them (3) months to finally diagnosed the cause.

At the time I was also physically very active, very good shape. To correct the problem at the time it was open heart surgery that wold have atleast 6 months time recovery.

The second alternative was medication, blood thinners, anti-depressants and anxiety medications. A personal note, I prior to this, I never understood depression how I treated it, I pushed through it, I was always a low-key and patient happy fellow.

The other alternative they also had a still rather new procedure where use a probe and they would put a plug in the hole. there was even one professional athlete that had it. But when I asked them if I can still be physical, work out, sports and the like, they could not answer that. So I waited (4) years until the medication wasn't working anymore.

By then it was an out patient procedure. I was in on Tuesday morning, they did the operation and I was out Wednesday. It was literally like a light bulb turning on.

I was going to write a segment here, mostly as a systems warning signs, and what to do if treatment is unsatisfactory. Just doe to what I went through, I would wish on nobody. But even as time past, it was hard to bring myself to it.

Bottom line, one can't put a price on ones own good health.

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#6
In reply to #5

Re: Regenerating Teeth

10/17/2014 6:17 AM

Hi Phoenix, Thanks for reply, it is educative. It is always will power which helps us. I do yoga to keep my heart beating @ 75 yrs age. God bless you and have long life.

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#7
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Re: Regenerating Teeth

10/17/2014 7:33 AM

Thank, so true, being in great shape is what saved me..

And lately at only 53,..... 54, I've been doing Swing dancing both West Cost and East Coast Swing. Great Cardio. Soon to take up Waltz.

And a good life to you also.

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#8

Re: Regenerating Teeth

11/04/2014 7:09 PM

Yes, there are devices that work through ultrasound that regenerate teeth. NOVASONIC and EXOGEN are two devices that are sold. Look for others. Look up Winston Price. He was a dentist that studied the teeth of tribes around the world a 100 years ago. He noticed that some tribes didn't have cavities even though they didn't brush their teeth. He concluded that it was diet, RAW milk, eggs, butter, etc are the things that do it. Fat soluable vitamins. Look up "Cure Tooth Decay" by Ramiel Nagel. Just that the unkosher foods, pure animal fat, and blood they recommend shouldn't be eaten. The Bible forbids them for a reason. We can talk more if you are interested in this.

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