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The Biomedical Engineering blog is the place for conversation and discussion about topics related to engineering principles of the medical field. Here, you'll find everything from discussions about emerging medical technologies to advances in medical research. The blog's owner, Chelsey H, is a graduate of Rensselaer Polytechnic Institute (RPI) with a degree in Biomedical Engineering.

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A Gluten Story, Part 1

Posted December 14, 2014 12:00 AM by Chelsey H

Humans have been eating wheat (and therefore gluten) for ten thousand years. For as much as we hear about gluten today I feel like it is still very much a mystery, especially after seeing videos like this.

Gluten is a protein. Actually, it's one of the most heavily consumed proteins on earth. It is created when the molecules glutenin and gliadin come into contact and form a bond. An elastic membrane is formed as bakers knead dough and the result is a chewy texture to the baked bread. Gluten also traps carbon dioxide which adds volume to the loaf as it ferments. Image Credit

Wheat provides more nourishment than any other source of food and last year's harvest amounted to roughly two hundred pounds for every person on earth. It is easy to grow, store, ship, and is especially versatile, serving as an integral part of bread, pasta, noodles, cereal, soups, sauces, gravies, and snack foods. Wheat is even found in processed meats and frozen vegetables - nearly a third of the foods found in American supermarkets contain some wheat component, usually gluten or starch or both.

So, how could gluten, a staple food that has sustained humanity for thousands of years, have suddenly become so threatening?

About one percent of the population suffers from celiac disease, a severe gluten allergy. Exposure to gluten can trigger an immune reaction powerful enough to severely damage the brushlike surface of the small intestine. The incidence of celiac disease has increase more than fourfold in the past sixty years. Another twenty million people complain of discomfort after eating gluten products and a third of American adults say that they are trying to eliminate it from their diets. At present, there are no blood tests, biopsies, genetic markers, or antibodies that can confirm a diagnosis of non-celiac gluten sensitivity.

There are many theories but no clear scientific answers. William Davis, a cardiologist who wrote the book "Wheat Belly," argues that wheat genes have become toxic and are nothing like the bread of 50 years ago. David Perlmutter, a neurologist and author of "Grain Brain: The Surprising Truth About Wheat" believes as many as forty percent of people can't properly process gluten. And several small scale studies have found that removing gluten from a test subject's diet reduces digestive discomfort.

It's no secret that dietary patterns in the Western world have changed faster than human genes have been able to adapt. Most meals are full of sugary substances and refined, high-calorie carbohydrates. The wheat that we use today has been milled into white flour with few vitamins or nutrients. However, a recent study published in the Journal of Agricultural and Food Chemistry found no evidence that a change in wheat-breeding practices might have led to an increase in the incidence of celiac disease. Other scientists agree that the wheat grain is not a lot different than it was fifty years ago. Image Credit

Wheat is more than just gluten - it is a combination of complex carbohydrates. An Australian team wondered if these could be responsible for the problems and devised another small scale study which identified FODMAPs, a type of carb that is found many types of foods that are high in fructose, like honey and apples as well as dairy products, like milk and ice cream. The study showed that FODMAPs might be the cause of digestive discomfort instead of the gluten. But these are harder to remove from a diet and harder for consumers to understand.

Gluten has been let out of the bag so to speak. The second part of this post will discuss how the process of making bread has changed over the years.

This blog is adapted from "Against The Grain"

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#1

Re: A Gluten Story, Part 1

12/15/2014 7:51 AM

If humans have been eating wheat for ten thousand years, we would have got adapted to all its contents including gluten. Only people who are allergic to gluten should avoid wheat. For that matter, one in million may be allergic to every common food. Nowadays, theories come out every now and then, condemning thing we were eating for thousands of years. Coconut oil being highly saturated fat, its consumption was considered most dangerous as it would lead to heart attack. But, people in Sri Lanka and Kerala, a southern state of India used this oil for centuries and continue to use it even today. But, as per statistics their life expectancy is the highest in Asia. How is it possible?. We should not come to conclusion without thorough study and research from various independent agencies.

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#2

Re: A Gluten Story, Part 1

12/15/2014 8:33 AM

If its shown up on face book, or has a "meme" or appears in Wikipedia then it must be true!.

Gotta love millenials.

What? But its the second day I showed up on time shouldn't I be getting a raise or something?

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#3

Re: A Gluten Story, Part 1

12/15/2014 9:14 AM

Yes, I very much agree with the allergic reaction possibility of wheat products, and possibly even that wheat has changed, although I can not prove that theory, although I must say Inever noticed a side effect from eating wheat products early in my life, just lately.

I stumbled onto the gluten thing by accident, as I slowly worked through a list of food products that I consumed during work days, but ate much less on weekends to figure out how to relieve my 5 "mad dash" trips to the restroom during almost every work day. After realizing I seldom ate wheat products on the weekends, instead focusing on meats, eggs, and cheeses, I removed such items from my work day menu, and I am now "mad dash" free. Just to prove my theory, some 2 months into the test, I ate a large pizza one Sunday, and come Monday morning, the "mad dash" resumed and continued into Tuesday. To some of us, gluten is not a good thing to eat. Five months into this experiment, I am still "mad dash" free. Now the question remains - is this an allergy brought on by the aging process and repeated exposures to gluten, or one from a change in the genetic structure of the wheat we eat?

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#4
In reply to #3

Re: A Gluten Story, Part 1

12/15/2014 9:46 AM

Growing up we grew most of what we consumed as food and my diet was simple with a minimum amount of sugar.

We ate a fairly large quantity of wheat bread and none of my family ever had any digestive issues.

Over the last 15 years all of my brothers and sisters have developed wheat allergy issues such as you have described with the only solution being to reduce or eliminate wheat entirely from our diets.

We have obtained non-genetically altered wheat directly from small farmers and ground it at home to make whole-wheat bread that does not cause any of us any digestive problems.

To me this alludes to the assumption either the chemicals being sprayed on the wheat in the field or used during processing at/in the factories , or the genetic structure of the wheat has changed enough that it has become a threat to humans.

Due to the possible decrease in profits of very large companies I am sure this will be no different than the RJ Reynolds Tobacco "discovery" with the real truth being suppressed and/or denied until the issues become so great that they can no longer be denied.

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#5

Re: A Gluten Story, Part 1

12/18/2014 4:04 PM

Gluten sensitivity (ciliac disease) seems to be brought on by a number of factors, but one of the primary ones is the combination of: (1) high estrogen levels in women with (2) high doses (probabably above what is recommended on the bottle) of acetaminophen. At least that is what caused my spouse's condition, based upon her story of what happened before she and I met.

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